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1、【pathogenesis of renal disease】uremiathe majority of diffuse renal disease result in progressive loss of these nephrons, whereas undamaged nephrons function normally to regulate body fluid and maintain a balance between intake and output of various dietary constituents. in renal insufficiency, the k

2、idneys are unable to clear the blood of urea and creatinine which are waste products of metabolism.(reduction in glomerular filtration area ) arf is a heterogeneous group of disorders, which is characterized by a sudden (within hours to days) deterioration of renal function and usually associated wi

3、th oliguria or anuria resulting in accumulation in the blood of nitrogenous wastes. 肾前性急性肾功能不全与急性肾小管坏死时尿液的比较 动脉血压80mmhg 肾血流自身调节作用 gfr 多尿期少尿期恢复期according to the urine volume, the progress course of oliguric type of arf may be divided into three stages: oliguric stage, polyuric stage and recovery stag

4、e. oliguric stage is often persists several daye to several weeks, which is the most dangerous stage because of severe disturbance of homeostasis. (oliguria、anuria and change of urinary component) crf is a syndrome of impaired homeostasis owing to structural damage (reduced functional nephrons) of kidneys. the disturbances are characterized by metabolic acidosis, hypocalcemia, hyperphos-phatemia, alteration in vitamin d metabolism and the presen

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