Research-Plan模版

1、Research Plan 模板 1：Advisors informationName:*Organization: Northwestern UniversityAcademic position: * ProfessorE-mail: *TEL: *Address: *, Chicago, IL 60611Research planBackground:A number of key transcription factors, including the Androgen Receptor, the Polycomb group protein EZH2,

2、 and the TMPRSS2:ERG gene fusions, have been related to epigenetic changes and implicated in prostate cancer. As transcriptional regulation, for instance those by EZH2, eventually leads to inheritable epigenetic changes and thus altered chromatin status. Epigenetic mechanisms may be fundamental to t

3、umorigenesis. Based on labs previous work, we hypothesized that in aggressive tumors altered transcriptional controls and chromatin states lead to de-differentiation and a stem cell like cellular status. In our study we will reveal the link between transcriptional control and epigenetic changes incl

4、uding histone methylation, DNA methylation and the regulation of miRNAs.Therefore the proposed work seeks to find the mechanisms between epigenetic regulation and prostate cancer. We plan to do the following projects:Project 1: Cell Culture and In Vitro Overexpression, Inhibition and Function Assays

5、.From November 2010 to February 2011, I will conduct experiments on: cell lines culture, expression vector construct, RNA analysis by RT-PCR.Project 2: Protein Interaction Assay, ChIP-Seq Assays and Bioinformatics Analysis.From March 2011 to August 2011, I will perform the Assays on: Protein interac

6、tion between target genes, Chromatin immunoprecipitation using the histone methylation antibody and sequence the DNA fragments, Search the binding site sequence by Bioinformatics analysis.Project 3: Paper Writing and PublicationFrom September 2011 to October 2011, I will write my research paper and

7、submit it to a high influence factor journal.Return planEpigenetic regulation, as one of the most fascinating research fields, has appeared in US & Europe since 2000s. Now this discipline has emerged as a new research frontier and received more and more attention in the world. However, in China,

8、 epigenetics has only received little attention compared to overseas. In many universities and institutes, few people concentrate on epigenetic regulation. So plenty of researchers will be needed to work on this discipline in the near future.With good expertise in epigenetic research including histo

9、ne methylation and DNA methylation acquired in National Key Laboratory of Crop Genetic Improvement (Huazhong Agricultural University) in past seven years and a deeper insight into epigenetic regulation that will be acquired in Northwestern University, I am full of confidence that after the completio

10、n of my post-doctoral research program, I will be able to find a suitable academic position in some university or institute in littoral of China or my home province. With good training in U.S and profound knowledge in epigenetics, I am confident of myself that I will be more competitive and have a m

11、uch better chance in China. In addition, I will share my research experience abroad with future colleagues in China.模板2：Descriptions of the research planTitle: Synthesis of Metal-Organic Compound (Grubbs and Schrock-type) Using for PolymerizationKeywords: polymer, asymmetric catalyst, mechanism, pol

12、ymerization1. Background and introduction of the research project:Conjugated polymers play an important role in various electronic applications. Apart from their conductivity, their photo- and electroluminescence properties are attracting great interest. Owing to their luminescence properties, they

13、are also used in several electronic applications, such as organic lightemitting diodes (OLEDs), solar cells, photovoltaic devices, lasers, all-plastic full-color image sensors, and field effect transistors. In principle, ternary systems, well-defined Mo-based Schrock-type catalysts and fluorocarboxy

14、late-modified Grubbs-type metathesis catalysts may be used for cyclopolymerization. Together with palladium-catalyzed reactions such as the Heck, Suzuki and Sonohashira-Hagihara reactions, metathesis reactions, particularly those that can be accomplished in an asymmetric way, belong nowadays to the

15、most important C-C coupling reactions. Due to the achievements made with catalysts necessary to accomplish these reactions, an almost unprecedented progress has been made in this area of research; nevertheless, the demand for new catalytic systems is a continuous and growing one. 2. The aim and expe

16、ction of the research project abroad:Its chemistry department can fulfill my project than any other domestic universities. Based on my professional knowledge, I can have a motivated research period and accomplish my Ph.D study. 3. The work plan after returning to China:After completing my Ph.D study

17、, I would like to return to my homeland and make use of my knowledges to serve the people. Now I submit my application with full confidence in the hope of winning a favorable permit. Many thanks for your kind consideration!Advisors informationName: +Organization: + UniversityAcademic position: +Prof

18、essor of +DirectorE-mail: *TEL: 831 *-*Address: *Research Plan 模板2：Background: +Project 1: +Form October 2010 to January 2011, I will conduct experiments on +Project 2: +From February 2011 to September 2011, I will investigate +Return planAfter one-year research in the United States, I will return to China to continue to be a college teacher in + Universi