蛋白质工程基础词汇

1、蛋白质工程基础词汇中英文对照表A degeneracy简并性alignment残基比对dhfr二氢叶酸还原酶aliphatic蛋白质脂质dihedral angle双面角alternative splicing可变剪接dipole-dipole interaction偶极-偶极相互作用amino acid residue氨基酸残基DNA-binding motifDNA结合模体amphipathicity两亲性DNA fragment replacement片段取代法amyloid淀粉样蛋白domain结构域ancestral gene始祖基因-domain structure型结构antip

2、arallel b-sheet反平行b层downstream下游antiphase magnetization反相位核磁化强度downstream box下游盒apo-Mb脱辅基肌红蛋白dystrophin肌营养不良蛋白 architecture构造Eat-the-time实时eclipsed conformation重叠构象Benhancer增强子backbone主链enthalpy焓bioavailability生物可提供性entropy熵build-up搭建方法episomal附加体b-bulgeb凸起exon外显子C export 外泌 calcium-binding motif钙结合

3、模体Fcalmodulin钙调蛋白F, finger指区cassette mutagenesis盒式突变法family家族CDRs互补决定区fibrinogen血纤蛋白原chaperonin伴侣蛋白flavodoxin黄素氧还蛋白chemical shift index化学位移索引flexibility柔性cis顺式flow反应流cistron顺反子folding折叠class类型fold recognition折叠辨识codon 密码子four helix bundle四螺旋束coherent transfer相干转移fusion phage融合噬菌体coiled-coil helix线绕式

4、螺旋Gcollectin集合素G, growth factor生长因子区complex motif复杂模型GCN4 leucine zipperGCN4亮氨酸拉链configuration构型globin fold珠状折叠conformation构象glucagon 胰高血糖素cosolvent共溶剂glycerol shock甘油休克处理g-crystalling晶体蛋白Greek key b barrel回纹式b桶折叠crystallin晶体蛋白Greek key motif希腊钥匙型模体CSI, chemical shift index化学位移索引growth factor生长因子区DH

5、DB下游盒b-hairpinb发夹hairpin b motif发夹式b模体b-b motifb-b模体hairpins发夹motif结构模体heat shock 热激，热休克mRNA信使核糖核酸heat stock protein热休克蛋白Nhelical wheel螺旋轮转nearest neighbor method 最近邻居方法-helix螺旋Neural network method神经网络方法helix-loop-helix螺旋-环链-螺旋non-productive strands非生产链helix-turn-helix motif螺旋-转折-螺旋模体Ohelper phage辅

6、助噬菌体oligomer寡聚体histogram网格图orientational取向homologous superfamily同源超家族overlap extension重叠延伸homology同源overlap region重叠区horseshoe fold 马蹄式折叠PHsp热休克蛋白P丝氨酸蛋白酶结构域hybrid system method混合方式parallel b-helix fold平行b螺旋折叠IParallel b-sheet平行b层image plate图像板parualbumin小白蛋白incoherent transfer非相干转移PCR聚合酶链式反应initiati

7、on-factor起始因子PDB, protein data bank蛋白质结构数据库intein蛋白内含子petidyl prolyl isomerase肽酰辅氨酰异构酶intron内含子phage display噬菌体显示技术Kphagemid噬菌粒knowledge-based method基于已有知识的预测方法phospholipid bicells磷脂双层盘状颗粒kringle铰链区b-pleated sheetb折叠层Lpolypeptide chain多肽链Lac operator Lac 操作子 primery structure一级结构lcucine-rich motif亮氨

8、酸模体priming region引导区linker scanning mutagenesis连接段扫描突变prion朊病毒lower bound下限promoter启动子Mprotein蛋白质magnetization transfer核磁化强度的转移protein denovo design蛋白质从头设计main chain主链protein fold assignment蛋白质折叠指派major coat protein gene多数外被蛋白基因 protein splicing蛋白质的剪接melton globule熔球体protein folding蛋白质的折叠metric matr

9、ix度量矩阵quaternary structure四级结构micelle分子内微泡Rminor coat protein gene少量外被蛋白基因refinement结构修正misorintation偏离release factor释放因子modeling模建reverse folding problem反向折叠问题molecular chaperone分子伴侣reverse trun回折ribosome核糖体TRNA polymeraseRNA聚合酶Tertiary三级结构rossman fold开放扭转式折叠thioxanthone三重态给体rotamer旋转异构体Threading m

10、ethod穿织法SThyroglobulin甲状腺球蛋白Secondrary structure二级结构TIM barreleTIM桶式折叠secretion分泌TNF-R1肿瘤坏死因子受体1sequence familv序列家族Topology拓扑学Sequence pattern序列模式Torsion angle扭角b-sheetb层t-PA组织血纤维蛋白溶酶原激活因子Site-directed mutagenesis定点突变trans反式Size exclusion chromatograghy尺寸排斥色谱Triosephosphate isomerase丙糖磷酸异构酶Solvent f

11、lattering溶剂平滑法troponin-C肌该蛋白CSplicing by overlap extension重叠延伸进行剪接Tumor necrosis factor receptor 1肿瘤坏死因子受体1Stagged conformation交错构象b-turnb转折Statistical method统计方法g-turng转折Stereospecific立体定向twisted strand肽链Stopped-flow流动停止技术two-sheet b helix双层b螺旋b-strandb链UStructural motif结构模体UAS, upstream activation sequences上游激活序列/b structure/b 型结构b-b unitb-b组合单位 -structure- 型结构up-and-down bbarrel上-下开放式b桶b- structureb 型结构up-and-down open b sheet上-下开放式