《纳米生物技术》教学大纲（英文版）.docx

1、'NanobiotechnologyJ Course SyllabusCourse Code： 09040009Course Category: Major ElectiveMajors: Chemistry (Intensive Training Class)Semester: FallTotal Hours： 36 HoursCredit： 2 学分Lecture Hours： 36 HoursLab Hours: 0 Hours Practice Hours: 0 HoursTextbooks：Nanobiotechnology: Concepts, Applications a

2、nd Perspectives，WILEY-VCH Edited by C. M. Niemeyer, C. A. MirkinReferences:1. X. Michalet, F. F. Pinaud, L. A. Bentolila, J. M. Tsay, S. Doose. J. J. Li, G. Sundaresan, A. M. Wu, S. S. Gambhir, S. Weiss,Science 2005, 307, 538.2.1. L. Medintz, H. T. Uyeda, E. R. Goldman, H. Mattoussi, Nat. Mater. 200

3、5, 4, 435.3. Mirkin, C. A.; Letsinger, R. L.; Mucic, R. C.； Storhoff, J. J. Nature 1996, 382, 607-609.4. N. L. Rosi, D. A. Giljohann, C. S. Thaxton, A. K. Lytton-Jean, M. S. Han, C. A. Mirkin, Science 2006,312, 1027.5. A. V. Pinheiro, D. Han, W. M. Shih, H. Yan Nat. Nanotechnol. 2011, 6, 763.Teachin

4、g Aim：This course will provide a general introduction to the newly emerging field of nanobiotcchnology. This is a highly interdisciplinary field covering nanotechnology, chemistry, biology, and medicine. The rapid development of this field has lead to a variety of nano architectures that could be ap

5、plied to biosensing, molecular imaging, and therapy, which is going to change our lives significantly. This is an advanced course for fourth-ycar students who have a solid background of chemistry and biochemistry, and those plan to purse a higher degree in the related field.Chapter I Introduction课时：

6、1周，共2课时Contents第一节 Introduclion、Definition of nanotechnology and nanobiotechnology二、Classification and preparation of nanoniatcrials三、Characterization methods四、Journals and search engine思考题Problems:1、What is nanobiotechnology?2 What is the difference between TEM, AFM and SEM?3、Please name five top j

7、ournals publishing research in the field of nanobiotechnologyChapter II Quantum Dots课时：6周，共12课时Contents第一节 Synthesis and properties一、Discovery of colloidal quantum dots二、Quantum confinement effect三、Optical properties四、Synthetic methods第二节 Types and compositions,、Binary and ternaiy quantum dots二、Type

8、 I and type II quantum dots三、Doped quantum dots四、Strain tuning第三节 B iofunctional ization一、Molecules for solubilization and functionalization二、Aqueous and one-step synthesis 第四节 QDs for biosensing、Fluorescence resonance energy transfer二、Nucleic acids detection三、Protease detection四、Bioluminescence res

9、onance energy transfer 第五节 QDs for bioimaging二、四、五、六、Molecular recognition ligandsIntracellular deliveryDesign consideration for in vivo imagingTumor imaging strategiesLymph node imagingDrug delivery and cancer therapy思考题Problems:1、What is quantum confinement effect and how does it determine the pho

10、toluminescence properties of QDs?2 Please design a FRET-based QD probe for sensitive detection of specific DNA molecules.3、What is the difference between passive and active tumor targeting?Chapter III Gold nanoparticles课时：3周，共6课时Contents第一节 Synthesis and properties、Discovery of gold nanoparticles二、S

11、ynthesis of gold nanoparticles, nanorods, and nanocages三、Optical properties of gold nanostructures 第二节 GNPs for biosensing二、四、五、Surface plasma resonanceProtease detectionNucleic acids detectionSmall molecule detectionSurface enhanced Raman scattering第三节 GNPs for drug delivery一、Surface functionalizat

12、ion二、Drug encapsulation and release三、Photothermal therapy思考题Problems：1、What is surface plasma resonance of gold nanoparticlcs?2 Please design a DNA detection method based on gold nanoparticle aggregation3、Please design a FRET-based gold nanoparticle probe for protease detectionChapter IV DNA nanotec

13、hnology 课时：3周，共6课时 第一节 DNA self-assembly、DNA chemical structure二、四、五、Secondary structure and assembly building blocksDNA-templatcd nanoparticlc assemblyDNA origamiDynamic assembly第二节 Applications % Biosensing 二、Drug delivery 思考题Problems:1、What are the advantages of DNA molecules for nanoscale assembly ?2