生理学-离子通道

1、生理学离子通道参赛者：杨金成，武琦From：医学1405Ion channelCategoriseAMechanism of action (Na-K pump)BIon channelopathyC voltage gated ion channelchemically gated ion channelmechanically gated ion channelExtracelluar:N2-Ach receptor、 GBAB receptor 、Gly receptor、NMDAR etc.Intracellular:cAMP、cGMP、G protein gated channel

2、etc.active transport the fundamental mode ATPaseinside: release 3Na+,bind 2K+ P.ATPase ATP ADP Drop Pioutside: Bind 3Na+，release 2K+ Na-K pump=ATPaseFunctions of Na-K pumpkeep the balance of ion inside and outside cellsthe basis of Ap and Rpkeep the size of cellsprovide energy of secondary active tr

3、ansport resting time: C K+：CNa+= 50100：1 efflux of K+ ions Net flux of k+=0 Diffusion force =electrical attractive force depolarizationstimulus Gna open Na+ internal flow CNa+Ck+(100:1) Fast Na+ internal flow Aps upslopeinactivate GNa+,Gk+ open RP efflux of K+ 钾离子病钾离子病：常染色体显性良性家族性新生儿（BFNC)、1-型发作性共济失

4、调、癫痫、阵发性舞蹈手足徐动症伴发作性共济失调等。 钠离子病：高钾型周期性麻痹、正常血钾型周期性麻痹、先天性副肌强直、先天性肌无力等。 钙离子病：家族性偏瘫型偏头痛、低钾型周期性瘫痪、恶性高热、中央脊髓性肌病等。 氯离子病：先天性肌强直(Thomsen型)、隐性遗传全身性肌强直(Becker型)、囊性纤维化病、遗传性肾结石病、 3-型Bartter综合征等。The definition of IIon channelopathy: The disease which is caused by the abnormity of ion channels structure and functions.(离子通道的结构或功能异常所引起的疾病)肌浆Ca导致TnC与Ca结合增强肌肉痉挛恶性高热. 疗法： 丹曲洛林（Dantrolene）是治疗恶性高热的特效药物。治疗的可能机制是通过抑制