厄贝沙坦联合美托洛尔治疗慢性充血性心衰的疗效观察

1、厄贝沙坦联合美托洛尔治疗慢性充血性心 衰的疗效观察摘要目的探讨厄贝沙坦联合美托洛尔治疗慢性充血 性心衰的疗效。方法 将 2014 年 1 月2016 年 10 月在我院老年医学科治疗的280 例慢性充血性心衰患者随机分为两组，对照组给予常规治疗，观察组在此基础上给予厄贝沙坦 联合美托洛尔治疗，比较两组患者的临床疗效、左心功能改 善情况、心率及血压情况。结果观察组临床有效率为95.00% ,明显高于对照组的 80.71%,两组差异有统计学意义； 观察组治疗后 LVEF、LVEDd、LVESd 明显较对照组改善， 两组差异有统计学意义；观察组治疗后HR、DBP、SBP 明显低于对照组，两组差异有统

2、计学意义；两组间不良反应发 生率无明显差异。结论 厄贝沙坦联合美托洛尔治疗慢性充血性心衰效果明确，利于降低心率和血压，改善左心功能， 具有积极的临床意义。关键词慢性充血性心衰；厄贝沙坦；美托洛尔；疗效 观察中图分类号R541.6+1 文献标识码B 文章编号1673-970118-0088-03Clinical observation of irbesartan combined with metoprolol inthe treatment of chronic congestive heart failureCHEN Xiaoyong ZHANG Lingli LIN ZiweiDepart

3、ment of General Medicine , Bozhou City People sHospital of Anhui Province , Bozhou 236800 , ChinaAbstract Objective To investigate the clinical effect ofirbesartan combined with metoprolol in the treatment of chroniccongestive heart failure. Methods A total of 280 patients with chroniccongestive hea

4、rt failure who were treated in the department ofgeriatrics from January 2014 to October 2016 were randomly dividedinto two groups. The control group received conventional therapy, theobservation group was treated with irbesartan combined withmetoprolol based on the treatment of the control group. Th

5、e clinicalefficacy , left heart function improvement, heart rate and bloodpressure between the two groups were compared. Results Theclinical effective rate was 95% in the observation group, significantlyhigher than 80.71% in the control group, and the difference wasstatistically significant. The LVE

6、F , LVEDd and LVESd in theobservation group were significantly higher than those in the controlgroup after treatment , and the difference was statistically significant.The HR ,DBP and SBP in theobservation group were significantly lower than those of the controlgroup , and the difference was statist

7、ically significant. There was nosignificant difference in the incidence of adverse reactions betweenthe two groups . Conclusions Irbesartan combined with metoprolol iseffective in the treatment of chronic congestive heart failure , which isbeneficial to reduce heart rate and blood pressure and improves leftventricular function. It has positive clinical significance.Key words Chronic congestive heart failure ; Irbesartan;Metoprolol ; Efficacy observation慢性充血性心衰是？R 床常见心脏疾病，病情危重，严 重威胁患者生命。本病多由器质性心脏疾病引起，是各种心 脏疾病的终末期结果，导致心肌损伤、心室负荷增大，心肌 收缩力受损，心室重构，从而引发的一系列症状1。临床可见