鼻咽肿瘤 颈部淋巴结 诱导化疗 毒副作用 多西他赛 顺铂 CT-sim TPS

1、鼻咽肿瘤论文：TP方案诱导化疗对、a期鼻咽癌颈部淋巴结消退作用及安全性的临床观察【中文摘要】观察TP方案诱导化疗对、a期鼻咽癌颈部淋巴结消退作用、毒副反应发生情况,评价TP方案诱导化疗的有效性、安全性。方法：36例经病理及影像学证实的、a期鼻咽癌行多西他赛(TXT)十顺铂(DDP)诱导化疗1周期,TXT75mg/m2,d1,DDP100mg/m2,d2-3。诱导化疗前一天、诱导化疗结束后(放疗开始前)分别行CT(西门子CT-模拟定位机siemens somatom emotion duo2003)扫描,用TPS(Pinnacle 7.4f)勾画CT扫描颈部淋巴结、计算体积,前后两者对比。诱导化

2、疗前、结束后1天、结束后1周分别检测血常规、T淋巴细胞、肝肾功,观察胃肠道毒性等毒副反应。采用SPSS17.0版统计软件分析,采用配对t检验比较诱导化疗前、后36例患者颈部淋巴结体积变化情况,诱导化疗前、结束后1天、结束后1周白细胞、中性粒细胞、红细胞、CD3、CD4、CD8、CD4/CD8变化情况,P0.05为差异有统计学意义；采用单个样本t检验分析T淋巴细胞与正常值差异,P0.05为差异有统计学意义。结果：CT结果显示诱导化疗结束后颈部淋巴结体积有明显缩小,平均缩小7.57.【英文摘要】:To observe the lymph nodes regression of、a nasophar

3、yngeal carcinoma(NPC) and adverse effect and toxic effect of inductive chemotherapy, evaluate the effectiveness and safety of TP program.Methods:From June 2010 to October 2010,36 patients with locally、a NPC were accepted by Department of First Affiliated Hospital of Guangxi Medical University,all th

4、e patients accepted TP(TXT+DDP) program inductive chemotherapy 1 cycle, TXT75mg/m2, d1, DDP100mg/m2, d2-3.The lymph nodes of neck were tested b.【关键词】鼻咽肿瘤 颈部淋巴结 诱导化疗 毒副作用 多西他赛 顺铂 CT-sim TPS【英文关键词】nasopharyngeal carcinoma(NPC) lymph nodes of neck induction chemotherapy TXT DDP adverse effect and toxic effect Siemens CT-sim TPS【索购全文】联系Q1：138113721 Q2：139938848【目录】TP方案诱导化疗对、a期鼻咽癌颈部淋巴结消退作用及安全性的临床观察摘要4-6ABSTRACT6-7前言8-12材料与方法12-14结果1