新一代核苷类似物 -- 阿德福韦酯

1、9648肝组织活检周周0肝组织活检研究研究 设计设计ADV 10 mg (n=171)ADV 30 mg (n=173)Placebo (n=167)Placebo (n=142)ADV 10 mg (n=138)Placebo (n=71)ADV 10 mg (n=85)The New England Journal of Medicine; 348:800807The New England Journal of Medicine; 348:800807log10 copies/mLaWilcoxon Rank-Sum TestThe New England Journal of Medi

2、cine; 348:800807The New England Journal of Medicine; 348:800807ALT 复常复常HBV DNA 1000拷贝拷贝/mlHBeAg 阴转阴转HBeAg 血清转换血清转换Long term efficacy and safety of adefovir dipivoxil 10mg in HBeAe+ CHB patients. Abstract 1135 (poster). 55th AASLD. October 29-November 2, 2004. Boston Abstract 1135 (poster). 研究研究 设计设计

3、9648肝组织活检肝组织活检周周0肝组织活检肝组织活检ADV 10 mg (n=123)ADV 10 mg (n=79)Placebo (n=40)Placebo (n=61)ADV 10 mg (n=60)The New England Journal of Medicine; 348:808816The New England Journal of Medicine; 348:808816The New England Journal of Medicine; 348:808816Log10(HBV DNA)The New England Journal of Medicine; 348:

4、808816ALT复常复常HBV DNA 1000 拷贝拷贝/ml39th Annual Meeting of the European Association for the Study of the Liver (EASL) in Berlin, Germany. aConfirmed (two consecutive laboratory abnormalities)The New England Journal of Medicine; 348:800807Journal of Hepatology 2004; 40(supppl.1): 20-21. Abstract 57Hepat

5、itis B: Update of Recommendations. Hepatology; 2004,39(3): 857-861. -5-4-3-2-101p0.001 与与 LAM相比相比ADV+LAM(n=19)ADV (n= 19)LAM (n=19)周周081624324048log10 copies/mLAdefovir Dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistance CHB. Gastroenterology; 2004, 126:91101ADV

6、+ LAMADVLAM患者(%)(n=19)(n=19)(n=19)Adefovir Dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistance CHB. Gastroenterology; 2004, 126:91101Adefovir Dipivoxil therapy for lamivudine-resistance hepatitis B in pre- and post-liver transplantation patients. Hepatology; 2003, 38:141927-5.0-4.0-3.0-2.0-1.00.0048 122436486072849648 1224364860728496Pre-transplantPost-transplant169肝移植后肝移植后161156 149116 88 57 43 27 24 15103肝移植前肝移植前 98 91 84 52 28 13 2 2 2 0log10 copies/mL/ohrms/dockets/ac/ 02/slides/3885S1_03_