任现职以来完成教学工作情况

1、任 现职以 来完成教学工作情况自何年月至何年月承担课程名称课程类别注册 听课 人数总学 时本人 承担 学时评估 结果2010.52010.6高等后机化学六年制研究 生基础课2230102011.52011.6高等后机化学六年制研究 生基础课2730102012.52012.6高等后机化学六年制研究 生基础课2530102012.92012.11生物分子成像及应 用研究生专业 课518182013.22013.3化学生物学概论研究生基础 课595492013.42013.5高等后机化学六年制研究 生基础课3030102013.22013.2生物分子成像及应 用研究生专业 课618182014.2

2、2014.3化学生物学概论研究生基础 课4554122014.52014.6高等有机化学六年制研究 生基础课3754102014.92014.11生物分子成像及应 用研究生专业 课418182015.32015.4化学生物学概论研究生基础 课4054122016.52015.6高等有机化学六年制研究 生基础课3054102015.92015.11生物分子成像及应 用研究生专业 课618182016.32016.4化学生物学概论研究生基础 课415412指导博士后2名，其中出站1名，指导博士生6名，其中毕业1名，指导硕士和六年制指导 研究 生情 况学生16名，其中毕业9名。指导 进修 人员 情况

3、课和验建的献 对程实室设贡承担六年制和研究生基础课高等后机化学和化学生物学概论，系统讲授有机化学中的周环反应、有机光化学，以及核酸的化学生物学；新开设研究生专业课分子成像 技术及应用，阐述分子成像的各种基本原理以及结合当前的国际上在分子成像领域的发 展，让研究生能对分子成像这一热门领域有更深一步的认识以及自己科研中可能遇到的成 像技术。紧密围绕着天然药物及仿生药物国家重点试验室传统优势的核酸和药物控释领域的发展方向，组建好了研究团队，开展了具有特色的核酸功能光调控，光控释放以及生物活性 分子荧光探针和肿瘤识别等领域的研究。在临 床实 践方 面的 主要 贝献对校 院系 管理 和社 会服 务的 主

4、要 贝瞅积极参与了 2011年天然药物及仿生药物国家重点实验室的验收和评估工作和2016年重点室评估的材料书写等准备工作2011-2013年研究生班主任。6任现职以来发表的论（译）著、教材、教学研究或在实验及其它科学技术工作方面的成果一、学术著作序号 全部作者 著作名称出版单位及出版时间本人贡献1.汤新景,Photochemistry,英国皇家化学会（RSC）,2013年，第十章 “Photochemical biology of caged nucleic acids ”二、教材序号 全部作者 教材名称出版单位及出版时间 本人贡献三、学术刊物论文（第一作者或通讯作者，刊物为核心期刊）序号全部

5、作者论著名称刊物名称及出版时间是否被收录他人引用情况独立开展工作以来以通讯作者已公开发表的研究论文：1. Yuzhuo Ji, Jiali Yang, Li Wu, Lijia Yu, Xinjing Tang* Photochemical Regulation of Gene Expression Using Caged siRNAs with Single Terminal Vitamin E Modification, Angew Chem Intl Ed.2016,55, 2152-2156 SC收录（影响因子 12.06）2. Xiuxian Chen, Qingqing Jin,

6、Lizhu Wu, ChenHo Tung, Xinjing Tang* Synthesis and Unique Photoluminescence Properties of Novel Nitrogen-rich Quantum dots and Their Applications, Angew Chem. Int. Ed, 2014, 53,12542-12547 SC收录（影响因子 12.06） 他引29次3. Li Wu, Yuan Wang, Junzhou Wu, Jie Wang, Xinjing Tang* Caged circular antisense oligonu

7、cleotides for photomodulation of RNA digestion and gene expression in cells. Nucleic Acids Res2013,41.677-686 SCI收录（影响因子 8.867）他引 7次4. Yuan Wang, Li Wu, Peng Wang, Cong Lv, Zhenjun Yang and Xinjing Tang* Manipulation of gene expression in zebrafish using caged circular morpholino oligomers Nucleic A

8、cids Res2012, 40, 11155-11162. SC收录（影响因子 8.867）他引 14次5. XinJing Tang*, Meng Su, LiLi Yu, Cong Lv, Jie Wang, and ZhongJin Li, Photomodulating RNA cleavage using photolabile antisense oligodeoxynucleotides Nucleic Acids Res2010, 38, 3848-3855 SCI收录（影响因子 8.867）他弓I 12 次6. Pengfei Li, Hongyan He, Zhixuan

9、 Wang, Mengke Feng, Hongwei Jin, Yun Wu, Liangren Zhang and Lihe Zhang, Xinjing Tang, Sensitive detection of single nucleotide mutation in BRAF mutation site （V600E） of human melanoma using phosphate-pyrene-labelled DNA probes Anal. Chem. 2016, 88, 883-889 SCI收录（影响因子 5.794）他弓I 1 次7. Zhisheng Wu, Xin

10、jing Tang*, Visualizing Fluoride ion in Mitochondria and Lysosome of Living Cells and in Living Mice with Positively Charged Ratiometric Probes Anal. Chem, 2015, 87, 8613-8617. SCI收录（影响因子 5.794）他弓I 2 次8. Long Li, Yuzhuo, Xinjing Tang *, Quaternary Ammonium Promoted Ultra Selective and Sensitive Fluo

11、rescence Detection of Fluoride Ion in Water and Living Cells, Anal. Chem., 2014, 86,10006-10009 SCI收录（影响因子 5.794）他引 10次9. Junzhou Wu, Duanwei Liang, Qingqing Jin, Jie Liu, Meiling Zheng Xuanming Duan, and Xinjing Tang*, Bioorthogonal SERS Nanoprobes for Mulitplex Spectroscopic Detection and Tumor Ce

12、ll Targeting and Tissue Imaging, Chem. Eur. J., 2015, 21,12914-12918. SCI收录（影响因子 5.635）10. Li Wu, Fen Pei, Jinhao Zhang, Junzhou Wu, Mengke Feng, Yuan Wang, Hongwei Jin, Liangren Zhang, Xinjing Tang* Synthesis of Site-specifically Phosphate-caged siRNAs and Evaluation of their RNAi Activity and Stab

13、ility, Chem. Eur. J., 2014, 20, 12114-12122 SCI收录（影响因子 5.635）11. Meng Su, Jie Wang, and XinJing Tang* , Photocaging strategy for functionalisation of oligonucleotides and its applications for oligonucleotide labelling and cyclisation Chem. Eur. J. 2012, 18, 9628-9637 SCI收录（影响因子 5.635）他弓I 6 次12. Jing

14、jing Sun, Xinjing Tang, Photouncaged Sequence-specific Interstrand DNA Cross-Linking with Photolabile 4-oxo-enalmodified Oligonucleotides Sci. Rep 2015, 5:10473 SCI收录（影响因子 5.597）13. Li Wu, Yujian He, Xinjing Tang*, Photoregulating RNA digestion using azobenzene linked dumbbell antisense oligodeoxynu

15、cleotides, Bioconjugate Chem. 2015, 26, 1070-1079 SCI收录（影响因子4.676）他引1次 并列通讯14. Zhisheng Wu, Mengke Feng, Xiuxian Chen, Xinjing Tang*, N-dots as photoluminescent probe for rapid and selective detection of Hg2+ and Ag+ in aqueous solution. J Mater. Chem. B 2016, 4, 2086-2089 SCI收录（影响因子 4.729）15. Cong

16、Lv, Zhen Wang, Peng Wang, and Xinjing Tang* Photodegradablepolyurethane self-assembled nanoparticles for photocontrollable release Langmuir 2012, 28, 9387-9394 SC收录（影响因子4.543）他引28次16. Wengang Ji, Yuzhuo Ji, Qingqing jin, Qingxiao Tong, Xinjing Tang*, Heavy Atom Quenched Coumarin Probes for Sensitive

17、 and Selective Detection of Biothiols in Living Cells, Analyst 2015,140,4379 - 4383 （影响因子 4.14）他引 2 次17. Bifeng Chen, Wei Li, Cong Lv, Manman Zhao, Hongwei Jin, Hongfang Jin, Junbao Du, Liangren Zhang, Xinjing Tang* Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide i

18、n living cells and cardiac tissues Analyst 2013, 138, 946-951 SC收录（影响因子4.14）他引54次18. Zhisheng Wu, Yongliang Feng, Bin Geng, Junyi Liu and Xinjing Tang* Fluorogenic sensing of H2s in blood and living cells via reduction of aromatic dialkylamino N-oxide, RSC Adv. 2014, 4, 30398W0401 SCI 收录（影响因子 3.907）

19、他引 3 次7b 19. Bifeng Chen, Cong Lv, Xinjing Tang* Chemoselective reduction-based fluorescence probe for detection of hydrogen sulfide in living cells Anal. Bioanal. Chem. 2012, 404, 1919-1923. SC收录（影响因子3.565）他引17次20. Pengfei Li, Jingjing Sun, Xiaogai Yang and XinJing Tang* Design, synthesis and prope

20、rties of artificial nucleic acids from （R）-4-amino-butane-1,3-diol, Org. Biomol. Chem., 2014,12, 2263-2272 SC收录（影响因子 3.382）他引 4次21. Bifeng Chen, Peng Wang, Qingqing Jin and Xinjing Tang* Chemoselective reduction and self-immolation based FRET probes for detecting hydrogen sulfide in solution and in

21、cells, Org. Biomol. Chem,. 2014, 12, 5629七633 SCI收录（影响因子 3.382）他引 14次22. Xinjing Tang ,* Jinhao Zhang, Jingjing Sun, Yuan Wang, Junzhou Wu and Lihe Zhang, Caged nucleotides/nucleosidesand their photochemical biology, Org. Biomol. Chem, 2013,11, 78143824 SCI收录（影响因子3.382）他引4次23. Zhen Wang, Peng Wang,

22、Xinjing Tang*, Synthesis of Light-Induced Expandable Photoresponsive Polymeric Nanoparticles for Triggered Release. hemPlusChem 2013, 78, 1273-1281 SCI收录（影响因子 2.997）他引2次24. Xinpeng Li, Yuan Wang, Jiajie Guo, and Xinjing Tang* Fluorescence detection of single-nucleotide polymorphism with single-stran

23、d triplex-forming DNA probes ChemBioChem2011, 12, 2863-2970 SCI收录（影响因子 3.162）他引 3 次25. Li Wu, Ya Wu, Hongwei Jin *, Liangren Zhang, Zhenjun Yang, Yujian He* and Xinjing Tang* Photoswitching property of ODN hairpins with azobenzenederivatives in the loop. Med. Chem. CommuR. 2015, 6, 461-468 SCI 收录（影响

24、因子 2.612）并列通讯26. Junzhou Wu, XinJing Tang* Synthesis and enzymatic incorporation of photolabile dUTP analogues into DNA and their applications for DNA labeling, Bioorg. Med. Chem., 2013, 21,6205-6211 SCI收录（影响因子 2.97）他弓I 3次27. Zhen Wang, Lili Yu, Cong Lv, Peng Wang, Yedong Chen, Xinjing Tang* Photore

25、sponsive Cross-linked Polymeric Particles for Phototriggered Burst Release, Photochem. Photobio2013, 89, 552-559 SC收录（影响因子 2.363）他引 1次28. LiLi Yu, Cong Lv, LiZhu Wu, ChenHo Tung, WanLiang Lv, ZhongJin Li, XinJing Tang*, Photosensitive cross-linked block copolymers with controllable release Photochem

26、. Photobio2011, 87, 646£52.SCI收录（影响因子 2.363）他引 13次29. Cong Lv, Zhen Wang, Peng Wang, and Xinjing Tang* Photodegradable polyesters for triggered releaselnt. J. Mol. Sci. 2012, 13, 16387-16399 SC收录（影响因子 2.983）他 引3次30. Cong Lv, LiLi Yu,Jie Wang, XinJing Tang*, A dumbbell molecular beacon for the s

27、pecific recognition of nucleic acids Bioorg. Med. Chem. Lett, 2010, 20, 6547-6550 SCI收录（影响因子2.317）他引6次31. Junzhou Wu, Jie Wang and XinJing Tang* Synthesis of photolabile dUTP analogues and their enzymatic incorporation for DNA labeling, Sci. China Chem. 2014, 57, 322-328 SCI收录（影响因子1.448）32. Peng Wan

28、g, Yuzhuo Ji, Zhixuan Wang,Xinjing Tang* , Supramolecular self-assembly for delivery of oligonucleotides and its phototriggered unpacking in living cells J. Chin. Pharma. Sci, 2014, 23（7）, 454-462 核心期刊33. Meng Su, Fan Yang, Cong Lv, LiLi Yu, XiaoYan Gu, Jie Wang, ZhongJin Li, XinJing Tang*, Photores

29、ponsive nucleic acids for gene regulation, J. Chin. Pharma. Sci., 2010, 19（1）, 5-14 核心期刊四、其他成果（分类列出专利、科研获奖、其他作者学术论文等）学术论文Li Wu, Xinjing Tang*, Synthesis of site-specifically phosphate-caged siRNA, Curr. Protoc. Nucleic Acid Chem2015, 61:6.12.1-6.12.15.发明专利：1 .汤新景，苏蒙，光敏感基团保护的功能基团亚磷酰胺及其制备方法和应用，专利 号：ZL 201210163013.12 .汤新景，苏蒙，光敏感的功能化周载相及其制备方法和应用，专利号：ZL201210162973.63 .汤新景，王珍，光敏感扩张性聚合物及其制备方法和应用，专利号：ZL 2013 10125594.44 .汤新景，吴骏宙，光可裂解基团保护的三磷酸脱氧尿甘衍生物及其合成方法和应 用， 专利号：ZL 2013 1 0125886.85 .汤新景，陈修贤，荧光富氮