Data collection, storage and presentation

1、Data collection, storage and presentationKate Fleming, Research AssociateDivision of Epidemiology and Public HealthYoung Investigator MeetingApril 28Data collection, storage and presentationOverviewData collectionWhy? What? How? Who? Where? When? EthicsData storage, entry and managementDatabasesChec

2、kingData presentationAnswer your research questionHow not to present your resultsYoung Investigator MeetingApril 28Data collection, storage and presentationWhy collect data?Without data, there would be no results!Without results, you have little to publish or present.Without publications or presenta

3、tions, you cannot establish yourself as a researcher.Young Investigator MeetingApril 28Data collection, storage and presentationWhat items of data should I collect?First question = What is my research question?e.g. Is it possible to diagnose cirrhosis without biopsy?What do I need to know to answer

4、this question?i.e. what items of data necessary?Young Investigator MeetingApril 28Data collection, storage and presentationHow should I collect my data? (1)Standardised proceduresCollection of biological samplesStorage conditions, size of sample, method of collection protocolLaboratory Use same assa

5、y, same reagents protocolAnimalsSubject to same conditions protocolYoung Investigator MeetingApril 28Data collection, storage and presentationHow should I collect my data? (2)Standardised proceduresClinical assessmentSame diagnostic criteria, same equipment protocolInterviewsValidated questionnaire,

6、 same circumstances protocolPROTOCOL!Young Investigator MeetingApril 28Data collection, storage and presentationWho should collect my data?Involve as few people as possible to remove variationProvide training if necessarye.g. blood samples phlebotomist, following protocolbilirubin in blood lab techn

7、ician, following protocolConsider blinding data collectors to research questionMe?Young Investigator MeetingApril 28Data collection, storage and presentationWhere and when should I collect my data?Depends on your research questionTry to make it as easy as possible for researchers and patientse.g. do

8、 not ask patient to attend extra clinic appointment to complete your questionnaireYoung Investigator MeetingApril 28Data collection, storage and presentationBefore starting to collect your datamake sure you have tested your methods of data collectionDo they work in the field?Could a new member of yo

9、ur team collect the data?e.g. provide documentation + flow-chartsPILOTPROTOCOLYoung Investigator MeetingApril 28Data collection, storage and presentationEthicsn., the rules of conduct recognized in respect to a particular class of human actions or a particular group, culture, etc.: medical ethics; W

10、orld Medical Associations Declaration of Helsinki ethical principles for medical research involving human subjectsHealth of patient must be first considerationPotential benefits must be in proportion to riskInformed consent and right to withdrawDetailed protocol for study should be submitted to appr

11、opriate ethical review committeeYoung Investigator MeetingApril 28Data collection, storage and presentationBest practiceGood clinical practice - Guidelines for studies involving medicationto protect trial subjectsto obtain reliable results/oc/gcp/regulations.html/

12、Content/Default.asp?PageID=130Good laboratory practiceto ensure quality and Animal experiment committeesYoung Investigator MeetingApril 28Data collection, storage and presentationDatabases and data entry (1)GIGO = Garbage In, Garbage OutDiscuss with statistician before start o

13、f studyStandardised proceduresData entry by trained individual (preferably 2)Electronic scanningData obtained from other computerized sourceDocument, document, document!Young Investigator MeetingApril 28Data collection, storage and presentationDatabases and data entry (2)Data checkingAt point of col

14、lectionAt entry, inbuilt within databasesCompare double entered dataSummarize data look for outliersArchive and back-upYoung Investigator MeetingApril 28Data collection, storage and presentationData linkageLink files togetheruse identifying code for each patient, sample etc. Once data complete break

15、 linkAnalysetalk to a statistician!Young Investigator MeetingApril 28Data collection, storage and presentationData presentation (1)Answer your research question!Summarize dataResults as expected?If not, why not? Errors in data? Go back and check again!Compare with other studiesSame? Different?Think

16、about possible reasons for differencesYoung Investigator MeetingApril 28Data collection, storage and presentationData presentation (2)Other findings i.e. not your primary research questionRemember negative findings are important tooBe honestYour study is probably not perfect limitations of your resultsYoung Investigator MeetingApril 28Data collection, storage and presentationHow n