Glucagon-Receptor-Agonists-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/Glucagon Receptor.html Glucagon HYPERLINK https:/www.MedChemE/Targets/Glucagon Receptor.html HYPERLINK https:/www.MedChemE/Targets/Glucagon Receptor.html ReceptorGCGRGlucagon receptor is in the G protein-coupled receptor family, that is important in controlling

2、 blood glucose levels. The glucagonreceptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family of receptors,coupled to G alpha i, Gs and to a lesser extent G alpha q. Stimulation of the receptor results in activation of adenylate cyclase andincr

3、eased levels of intracellular cAMP. In humans, the glucagon receptor is encoded by the GCGR gene. Glucagon receptors aremainly expressed in liver and in kidney with lesser amounts found in heart, adipose tissue, spleen, thymus, adrenal glands, pancreas,cerebral cortex, and gastrointestinal tract.www

4、.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Glucagon Receptor.html Glucagon HYPERLINK https:/www.MedChemE/Targets/Glucagon Receptor.html HYPERLINK https:/www.MedChemE/Targets/Glucagon Receptor.html Receptor HYPERLINK https:/www.MedChemE/Targets/Glucagon Receptor.html HYPERLINK https:/www.MedCh

5、emE/Targets/Glucagon Receptor.html Inhibitors, HYPERLINK https:/www.MedChemE/Targets/Glucagon Receptor.html HYPERLINK https:/www.MedChemE/Targets/Glucagon Receptor.html Agonists, HYPERLINK https:/www.MedChemE/Targets/Glucagon Receptor.html HYPERLINK https:/www.MedChemE/Targets/Glucagon Receptor.html

6、 Antagonists HYPERLINK https:/www.MedChemE/Targets/Glucagon Receptor.html HYPERLINK https:/www.MedChemE/Targets/Glucagon Receptor.html & HYPERLINK https:/www.MedChemE/Targets/Glucagon Receptor.html HYPERLINK https:/www.MedChemE/Targets/Glucagon Receptor.html Modulators HYPERLINK https:/www.MedChemE/

7、Adomeglivant.html Adomeglivant(LY2409021) Cat. No.: HY-19904 HYPERLINK https:/www.MedChemE/albiglutide-tfa.html Albiglutide HYPERLINK https:/www.MedChemE/albiglutide-tfa.html HYPERLINK https:/www.MedChemE/albiglutide-tfa.html TFACat. No.: HY-108795AAdomeglivant (LY2409021) is a potent, selectivegluc

8、agon receptor (GluR) allosteric antagonist.Adomeglivant is widely used in the research fortype 2 diabetes mellitus.Albiglutide TFA, a glucagon-like peptide (GLP)-1mimetic, is a long acting GLP-1 receptor agonistfor the treatment of type 2 diabetes mellitus(T2DM). Albiglutide TFA is generated by theg

9、enetic fusion of a DPP-4-resistant GLP-1 dimer tohuman albumin.Purity: 98.18%Clinical Data: Phase 2Size: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 97.51%Clinical Data: LaunchedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Exendin_9-39.html Avexitide(Exendin (9-39) Cat. No.: HY-P0264 HYPE

10、RLINK https:/www.MedChemE/bay-55-9837.html Bay HYPERLINK https:/www.MedChemE/bay-55-9837.html HYPERLINK https:/www.MedChemE/bay-55-9837.html 55-9837Cat. No.: HY-P1160Avexitide (Exendin (9-39) is a specific andcompetitive GLP-1 receptor antagonist.Bay 55-9837 is a potent and highly selectiveagonist o

11、f VPAC2, with a K of 0.65 nM. Bayd55-9837 may be a useful therapy for the researchof type 2 diabetes.Purity: 99.70%Clinical Data: Phase 2Size: 500 g, 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/bay-55-9837-tfa.html Bay HYPERLINK https:/ww

12、w.MedChemE/bay-55-9837-tfa.html HYPERLINK https:/www.MedChemE/bay-55-9837-tfa.html 55-9837 HYPERLINK https:/www.MedChemE/bay-55-9837-tfa.html HYPERLINK https:/www.MedChemE/bay-55-9837-tfa.html TFA HYPERLINK https:/www.MedChemE/bay-55-9837-tfa.html HYPERLINK https:/www.MedChemE/BETP.html BETPCat. No.

13、: HY-P1160A Cat. No.: HY-103546Bay 55-9837 TFA is a potent and highly selectiveagonist of VPAC2, with a K of 0.65 nM. Bayd55-9837 TFA may be a useful therapy for theresearch of type 2 diabetes.BETP is an agonist of glucagon-like peptide-1(GLP-1) receptor, with EC s of 0.66 and 0.75550M for human and

14、 rat GLP-1 receptor,respectively.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.28%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/cochinchinenin-c.html Cochinchinenin HYPERLINK https:/www.MedChemE/c

15、ochinchinenin-c.html HYPERLINK https:/www.MedChemE/cochinchinenin-c.html C HYPERLINK https:/www.MedChemE/cochinchinenin-c.html HYPERLINK https:/www.MedChemE/cotadutide-acetate.html Cotadutide HYPERLINK https:/www.MedChemE/cotadutide-acetate.html HYPERLINK https:/www.MedChemE/cotadutide-acetate.html

16、acetateCat. No.: HY-N2452(MEDI0382 acetate) Cat. No.: HY-P2231ACochinchinenin C is a nonpolypeptide agonist ofglucagon-like peptide-1 (GLP-1) receptor.Cochinchinenin C can be used for the research ofdiabetes.Cotadutide acetate (MEDI0382 acetate) is a potentpeptide dual agonist ofglucagon-like peptid

17、e-1 (GLP-1)and glucagon receptor with EC values50of 6.9 pM and 10.2 pM, respectively.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.01%Clinical Data: Phase 2Size: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/dapiglutide.html Dapiglutide HYPERLINK https:/www.MedChemE/

18、dapiglutide.html HYPERLINK https:/www.MedChemE/ecnoglutide.html Ecnoglutide(ZP7570) Cat. No.: HY-P3291Cat. No.: HY-P3366Dapiglutide (ZP7570) is a long-acting glucagon-likepeptide-1 receptor 1R (GLP-1R)/Glucagon-likepeptide-2 receptor (GLP-2R) dual agonist.Dapiglutide can be used for short bowel synd

19、rome(SBS) research.Ecnoglutide is a glucagon-like peptide 1 (GLP-1)receptor agonist.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChe

20、mE/exendin-5-39.html Exendin HYPERLINK https:/www.MedChemE/exendin-5-39.html HYPERLINK https:/www.MedChemE/exendin-5-39.html (5-39) HYPERLINK https:/www.MedChemE/exendin-5-39.html HYPERLINK https:/www.MedChemE/KQMEEEAVRLFIEWLKNGGPSSGAPPPS.html Exendin-3/4 HYPERLINK https:/www.MedChemE/KQMEEEAVRLFIEW

21、LKNGGPSSGAPPPS.html HYPERLINK https:/www.MedChemE/KQMEEEAVRLFIEWLKNGGPSSGAPPPS.html (59-86)Cat. No.: HY-P2497 Cat. No.: HY-P1223Exendin (5-39) is a potent glucagon-like peptide 1(GLP-1) receptor antagonist. Exendin (5-39)improves memory impairment in -amyloidprotein-treated rats.Exendin-3/4 (59-86)

22、is a Exendin-4 peptidederivative.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 97.75%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/Exendin-4.html Exendin-4(Exenatide) Cat. No.: HY-13443 HYPERLINK https:/www.MedChemE/Exendin-4_A

23、cetate.html Exendin-4 HYPERLINK https:/www.MedChemE/Exendin-4_Acetate.html HYPERLINK https:/www.MedChemE/Exendin-4_Acetate.html acetate(Exenatide acetate) Cat. No.: HY-13443AExendin-4 (Exenatide), a 39 amino acid peptide, isa long-acting glucagon-like peptide-1 receptoragonist with an IC of 3.22 nM.

24、50Exendin-4 acetate (Exenatide acetate), a 39 aminoacid peptide, is a long-acting glucagon-likepeptide-1 receptor agonist with an IC of 3.2250nM.Purity: 99.98%Clinical Data: Phase 4Size: 1 mg, 5 mg, 10 mg, 25 mgPurity: 99.44%Clinical Data: Phase 4Size: 1 mg, 5 mg, 10 mg, 25 mg HYPERLINK https:/www.M

25、edChemE/FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS.html FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS HYPERLINK https:/www.MedChemE/FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS.html HYPERLINK https:/www.MedChemE/GLP-1_moiety_from_Dulaglitude.html GLP-1 HYPERLINK https:/www.MedChemE/GLP-1_moiety_from_Dulaglitude.html HYPERLINK h

26、ttps:/www.MedChemE/GLP-1_moiety_from_Dulaglitude.html moiety HYPERLINK https:/www.MedChemE/GLP-1_moiety_from_Dulaglitude.html HYPERLINK https:/www.MedChemE/GLP-1_moiety_from_Dulaglitude.html from HYPERLINK https:/www.MedChemE/GLP-1_moiety_from_Dulaglitude.html HYPERLINK https:/www.MedChemE/GLP-1_moi

27、ety_from_Dulaglitude.html DulaglutideCat. No.: HY-P1229 Cat. No.: HY-P1348FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS is anExendin-4 peptide derivative.GLP-1 moiety from Dulaglutide is a 31-amino acidfragment of Dulaglutide which is a glucagon-likepeptide 1 receptor (GLP-1) agonist, extracted frompatent US 2

28、0160369010 A1.Purity: 98.01%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 95.81%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/GLP-1_receptor_agonist-1.html GLP-1 HYPERLINK https:/www.MedChemE/GLP-1_receptor_agonist-1.html HYPERLINK https:

29、/www.MedChemE/GLP-1_receptor_agonist-1.html receptor HYPERLINK https:/www.MedChemE/GLP-1_receptor_agonist-1.html HYPERLINK https:/www.MedChemE/GLP-1_receptor_agonist-1.html agonist HYPERLINK https:/www.MedChemE/GLP-1_receptor_agonist-1.html HYPERLINK https:/www.MedChemE/GLP-1_receptor_agonist-1.html

30、 2 HYPERLINK https:/www.MedChemE/GLP-1_receptor_agonist-1.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-3.html GLP-1 HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-3.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-3.html receptor HYPERLINK https:/www.MedChemE/glp-1-recept

31、or-agonist-3.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-3.html agonist HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-3.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-3.html 3Cat. No.: HY-112679 Cat. No.: HY-129656GLP-1 receptor agonist 2 is a glucagon-likepeptide-1 r

32、eceptor (GLP-1R) agonist.GLP-1 receptor agonist 3 is a GLP-1 receptoragonist extracted from patent WO2018109607A1,Example 4A-1, has EC s of 1.1 nM and 13 nM in50Clone H6 and Clone C6 cell lines assay,respectively.Purity: 99.15%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 m

33、g, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-4.html GLP-1 HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-4.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-4.html receptor HYPERLINK https:/www.Me

34、dChemE/glp-1-receptor-agonist-4.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-4.html agonist HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-4.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-4.html 4 HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-4.html HYPERLINK htt

35、ps:/www.MedChemE/glp-1-receptor-agonist-7.html GLP-1 HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-7.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-7.html receptor HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-7.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-7.htm

36、l agonist HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-7.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-7.html 7Cat. No.: HY-129657 Cat. No.: HY-145412GLP-1 receptor agonist 4 is a glucagon-likepeptide-1 receptor (GLP-1R) agonist extractedfrom patent WO2009111700A2, compound 87, h

37、as anEC of 64.5 nM. GLP-1 receptor agonist 4 can be50used in the research for treatment of diabetes.GLP-1 receptor agonist 7 is a potent agonist ofglucagon-like peptide-1 (GLP-1). GLP-1 receptoragonist 7 has the potential for the research ofGLP-1-associated diseases, disorders, andconditions includi

38、ng diabetes mellitus (extractedfrom patent WO2021219019A1, compound 130b).Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-8.html GLP-1 HYPERLINK https

39、:/www.MedChemE/glp-1-receptor-agonist-8.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-8.html receptor HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-8.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-8.html agonist HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-8.htm

40、l HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-8.html 8 HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-8.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-9.html GLP-1 HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-9.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agoni

41、st-9.html receptor HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-9.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-9.html agonist HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-9.html HYPERLINK https:/www.MedChemE/glp-1-receptor-agonist-9.html 9Cat. No.: HY-138996 Cat. No.: HY

42、-145458GLP-1 receptor agonist 8 is a potent agonist ofGLP-1 R. GLP-1 receptor agonist 8 has thepotential for the research of diabetes, obesity,and nonalcoholic fatty liver disease (NAFLD)(extracted from patent WO2019239319A1, compound17).GLP-1 receptor agonist 9 is a GLP-1 receptoragonist, example 7

43、, extracted from WO2020234726A1.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/glp-1-28-36-amide.html GLP-1(28-36)amide HYPERLINK https:/www.MedChemE/glp-1-28-36-amide.html HYPERLINK htt

44、ps:/www.MedChemE/glp-1-28-36-amide-tfa.html GLP-1(28-36)amide HYPERLINK https:/www.MedChemE/glp-1-28-36-amide-tfa.html HYPERLINK https:/www.MedChemE/glp-1-28-36-amide-tfa.html TFACat. No.: HY-P3101 Cat. No.: HY-P3101AGLP-1(28-36)amide, a C-terminal nonapeptide ofGLP-1, is a major product derived fro

45、m thecleavage of GLP-1 by the neutral endopeptidase(NEP). GLP-1(28-36)amide is an antioxidant andtargets to mitochondrion, inhibits mitochondrialpermeability transition (MPT).GLP-1(28-36)amide TFA, a C-terminal nonapeptide ofGLP-1, is a major product derived from thecleavage of GLP-1 by the neutral

46、endopeptidase(NEP). GLP-1(28-36)amide TFA is an antioxidant andtargets to mitochondrion, inhibits mitochondrialpermeability transition (MPT).Purity: 96.08%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.Med

47、ChemE/glp-1-32-36-amide.html GLP-1(32-36)amide HYPERLINK https:/www.MedChemE/glp-1-32-36-amide.html HYPERLINK https:/www.MedChemE/glp-1-32-36-amide-tfa.html GLP-1(32-36)amide HYPERLINK https:/www.MedChemE/glp-1-32-36-amide-tfa.html HYPERLINK https:/www.MedChemE/glp-1-32-36-amide-tfa.html TFACat. No.

48、: HY-P3102 Cat. No.: HY-P3102AGLP-1(32-36)amide, a pentapeptide, derived fromthe C terminus of the glucoregulatory hormoneGLP-1. GLP-1(32-36)amide could inhibit weight gainand modulate whole body glucose metabolism indiabetic mice.GLP-1(32-36)amide TFA, a pentapeptide, derivedfrom the C terminus of

49、the glucoregulatory hormoneGLP-1. GLP-1(32-36)amide TFA could inhibit weightgain and modulate whole body glucose metabolism indiabetic mice.Purity: 98.43%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedC

50、hemE/Glucagon-Like_Peptide_GLP_I_7-36_,_amide,_human.html GLP-1(7-36), HYPERLINK https:/www.MedChemE/Glucagon-Like_Peptide_GLP_I_7-36_,_amide,_human.html HYPERLINK https:/www.MedChemE/Glucagon-Like_Peptide_GLP_I_7-36_,_amide,_human.html amide HYPERLINK https:/www.MedChemE/Glucagon-Like_Peptide_GLP_I

51、_7-36_,_amide,_human.html (Glucagon-like peptide-1 (GLP-1)(7-36), HYPERLINK https:/www.MedChemE/GLP-17-36.html GLP-1(7-36), HYPERLINK https:/www.MedChemE/GLP-17-36.html HYPERLINK https:/www.MedChemE/GLP-17-36.html amide HYPERLINK https:/www.MedChemE/GLP-17-36.html HYPERLINK https:/www.MedChemE/GLP-1

52、7-36.html acetate HYPERLINK https:/www.MedChemE/GLP-17-36.html (Glucagon-like peptide-1amide; Human GLP-1 (7-36), amide) Cat. No.: HY-P0054A (GLP-1)(7-36), amide acetate; ) Cat. No.: HY-P0054GLP-1(7-36), amide is a physiological incretinhormone that stimulates insulin secretion.GLP-1(7-36), amide ac

53、etate is a major intestinalhormone that stimulates glucose-induced insulinsecretion from cells.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.62%Clinical Data: No Development ReportedSize: 500 g, 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/glp-1-7-36-amide-tfa.html G

54、LP-1(7-36), HYPERLINK https:/www.MedChemE/glp-1-7-36-amide-tfa.html HYPERLINK https:/www.MedChemE/glp-1-7-36-amide-tfa.html amide HYPERLINK https:/www.MedChemE/glp-1-7-36-amide-tfa.html HYPERLINK https:/www.MedChemE/glp-1-7-36-amide-tfa.html TFA HYPERLINK https:/www.MedChemE/glp-1-7-36-amide-tfa.htm

55、l (Glucagon-like peptide-1 HYPERLINK https:/www.MedChemE/GLP-17-37.html GLP-1(7-37)(GLP-1)(7-36), amide TFA; Human GLP-1 (7-36), amide TFA) Cat. No.: HY-P0054BCat. No.: HY-P0055GLP-1(7-36), amide TFA is a major intestinalhormone that stimulates glucose-induced insulinsecretion from cells.GLP-1(7-37)

56、 is an intestinal insulinotropichormone that augments glucose induced insulinsecretion.Purity: 99.20%Clinical Data: No Development ReportedSize: 500 g, 1 mg, 5 mg, 10 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg, 25 mg4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMe

57、dChemE HYPERLINK https:/www.MedChemE/GLP-1_7-37_acetate.html GLP-1(7-37) HYPERLINK https:/www.MedChemE/GLP-1_7-37_acetate.html HYPERLINK https:/www.MedChemE/GLP-1_7-37_acetate.html acetate HYPERLINK https:/www.MedChemE/GLP-1_7-37_acetate.html HYPERLINK https:/www.MedChemE/glp-1-9-36-amide.html GLP-1

58、(9-36)amideCat. No.: HY-P0055A Cat. No.: HY-P1141GLP-1(7-37) acetate is an intestinalinsulinotropic hormone that augments glucoseinduced insulin secretion.GLP-1(9-36)amide is a major metabolite ofglucagon-like peptide-1-(7-36) amide formed by theenzyme dipeptidyl peptidase-4 (DPP-4).GLP-1(9-36)amide

59、 acts as an antagonist to thehuman pancreatic GLP-1 receptor.Purity: 99.33%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg, 25 mgPurity: 99.20%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/glp-1-9-36-amide-tfa.html GLP-1(9-36)amide HYPERLINK https

60、:/www.MedChemE/glp-1-9-36-amide-tfa.html HYPERLINK https:/www.MedChemE/glp-1-9-36-amide-tfa.html TFA HYPERLINK https:/www.MedChemE/glp-1-9-36-amide-tfa.html HYPERLINK https:/www.MedChemE/glp-1r-agonist-1.html GLP-1R HYPERLINK https:/www.MedChemE/glp-1r-agonist-1.html HYPERLINK https:/www.MedChemE/gl