Lidocaine-hydrochloride-Lignocaine-hydrochloride-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELidocaine hydrochlorideCat. No.: HY-B0185ACAS No.: 73-78-9Synonyms: Lignocaine hydrochloride分式: CHClNO分量: 270.8作靶点: Sodium Channel; MEK; ERK; NF-B作通路: Membrane Transporter/Ion Channel; MAPK/ERK Pathway;Stem Cell/Wnt; NF-B储存式: 4C

2、, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据体外实验 H2O : 36 mg/mL (132.94 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.6928 mL 18.4638 mL 36.9276 mL5 mM 0.7386 mL 3.6928 mL 7.3855 mL10 mM 0.3693 mL 1.8464 m

3、L 3.6928 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Lidocaine hydrochloride (Lignocaine hydrochloride) 抑制涉及复杂电压和依赖性的钠通道 (sodiumchannels)。Lidocaine hydrochloride 通过调节 miR-145 表达和进步抑制 MEK/ERK 和 NF-B 信号通路来减少胃癌细胞的长，迁移和侵袭。Lidocaine hydrochloride 种常的酰胺衍物局部醉剂，种治疗室性律失常的药物和有效的肿瘤抑制剂。

4、1/3 Master of Small Molecules 您边的抑制剂师www.MedChemEIC50 & Target MEK ERK NF-B体外研究 Lidocaine hydrochloride (Lignocaine hydrochloride) (10 nM; 48 hours) decreases significantly cellproliferation 2.Lidocaine hydrochloride (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressingeff

5、ects at the concentration of 10nM and treatment time 48hours 2.Lidocaine hydrochloride (10 nM; 48 hours) increases significantly the apoptotic cell rate 2.Lidocaine hydrochloride (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expressionsignificantly 2.Cell Proliferation Assay 2Cell

6、Line: The human gastric cancer cell line MKN45Concentration: 10nMIncubation Time: 48 hoursResult: Decreased significantly cell proliferation.Cell Viability Assay 2Cell Line: The human gastric cancer cell line MKN45Concentration: 1, 5 and 10nMIncubation Time: 24, 48, 72 hoursResult: Inhibited MKN45 c

7、ell viability.Apoptosis Analysis 2Cell Line: The human gastric cancer cell line MKN45Concentration: 10nMIncubation Time: 48 hoursResult: Increased significantly the apoptotic cell rate.Western Blot Analysis 2Cell Line: The human gastric cancer cell line MKN45Concentration: 10nMIncubation Time: 48 ho

8、ursResult: Down-regulated Cyclin D1 and up-regulated p21 expression significantly.2/3 Master of Small Molecules 您边的抑制剂师www.MedChemE体内研究 Lidocaine hydrochloride (Lignocaine hydrochloride) causes completely reversible tail nerve block in rats.Mechanical nociception block produced by lidocaine has slow

9、er onset and faster recovery compared withthermal nociception block 3.户使本产品发表的科研献 J Neuroinflammation. 2017 Nov 2;14(1):211. J Phys D Appl Phys. 2019 Aug.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Cummins TR, et al. Setting up for the block: the mechanism underlying lidoca

10、ines use-dependent inhibition of sodium channels. JPhysiol. 2007 Jul 1;582(Pt 1):11.2. Sui H, et al. Lidocaine inhibits growth, migration and invasion of gastric carcinoma cells by up-regulation of miR-145. BMC Cancer. 2019Mar 15;19(1):233.3. Li Z, et al. Evaluation of the antinociceptive effects of lidocaine and bupivacaine on the tail nerves of healthy rats. Basic Clin PharmacolToxicol. 2013 Jul;113(1):31-6.McePdfHeightCaution: Product has not been full