minus-Menthol-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE(-)-MentholCat. No.: HY-75161CAS No.: 2216-51-5分式: CHO分量: 156.27作靶点: TRP Channel作通路: Membrane Transporter/Ion Channel; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100

2、mg/mL (639.92 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 6.3992 mL 31.9959 mL 63.9918 mL5 mM 1.2798 mL 6.3992 mL 12.7984 mL10 mM 0.6399 mL 3.1996 mL 6.3992 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，

3、建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (16.00 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (16.00 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubi

4、lity: 2.5 mg/mL (16.00 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 (-)-Menthol是薄荷油的关键成分，(-)-Menthol 结合并激活瞬瞬时受体电位 M8 (TRPM8)，TRPM8是Ca2+-可渗透的选择性阳离通道，最终增加 Ca2+i 1。 具有抗肿瘤活性 1。IC50 & Target TRPM8 1体外研究 (-)-Menthol (Menthol ) per se does not exhibit antiproli

5、ferative activity, but it is able to enhance 1,25(OH)2D3-mediated growth inhibition in LNCaP cells. At high (-)-Menthol concentrations above 1.6 mM, thecells begin to detach from the culture dish 1.(-)-Menthol (0.8 mM) can increase Ca2+i via transmembrane influx or store release pathways. Peakincrea

6、se in Ca2+i was 102.339 nM (n=3) in (-)-Menthol alone and 124.551 nM (n=3) in combination of 1,25(OH)2D3 with (-)-Menthol, respectively 1.Combination of 1,25(OH)2D3 with (-)-Menthol (0.8 mM) cooperatively modulates bcl-2 and p21 expression1.REFERENCES1. Park EJ, et al. Menthol Enhances an Antiproliferative Activity of 1alpha,25-Dihydroxyvitamin D(3) in LNCaP Cells. J Clin Biochem Nutr.2009 Mar;44(2):125-30.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.T