Asenapine-Org-5222-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAsenapineCat. No.: HY-10121CAS No.: 65576-45-6Synonyms: Org 5222分式: CHClNO分量: 285.77作靶点: 5-HT Receptor; Adrenergic Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 m

2、onth溶解性数据体外实验 DMSO : 50 mg/mL (174.97 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.75 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (8.75 mM); Suspended solution; Need ultrasonic1/2 Master of Small Molecules 您边的抑制剂师ww

3、w.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (8.75 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Asenapine(Org 5222)能抑制肾上腺素受体，对1，2A，2B和2C的Ki为0.25-1.2 nM，还能抑制 5-HT受体，对1A，1B，2A，2B，2C，5A，6和7的Ki为0.03-4.0 nM。REFERENCES1. Stoner SC, Pace HA. Asenapine: a clinical review of a second-gener

4、ation antipsychotic. Clin Ther. 2012 May;34(5):1023-40.2. Tarazi FI, Shahid M. Asenapine maleate: a new drug for the treatment of schizophrenia and bipolar mania. Drugs Today (Barc). 2009Dec;45(12):865-76.3. Elsworth JD, Groman SM, Jentsch JD et al. Asenapine effects on cognitive and monoamine dysfu

5、nction elicited by subchronicphencyclidine administration. Neuropharmacology. 2012 Mar;62(3):1442-52.4. Potkin SG. Asenapine: a clinical overview. J Clin Psychiatry. 2011;72 Suppl 1:14-8.5. Shahid M, Walker GB, Zorn SH, Wong EH. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. JPsychopharmacol. 2009 Jan;23(1):65-73.6. AsenapineMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;