Perillartine-DL-Perillartine-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPerillartineCat. No.: HY-N2084CAS No.: 30950-27-7Synonyms: DL-Perillartine分式: CHNO分量: 165.23作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (605.22 mM)H2O :

2、40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (15.13 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (15.13 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (15.13 mM); Clea

3、r solutionBIOLOGICAL ACTIVITY物活性 Perillartine种甜味剂，激活味觉受体 1 型成员 2 (TAS1R2)。IC50 & Target TAS1R2 1体外研究 The responses of the monomeric Tas1r2 subunits of human, rhesus monkey, squirrel monkey and mouse toPerillartine are examined, respectively. The human, rhesus monkey and squirrel monkey Tas1r2 subuni

4、tscan be activated by Perillartine, while mouse Tas1r2 can not. The insensitivity of human, rhesus monkey,squirrel monkey and mouse Tas1r2 subunits to cyclamate precludes the probable involvement of Tas1r3subunit in the assay. Replacement of the mouse Tas1r2 with rhesus monkey Tas1r2 (rhTas1r2/mTas1

5、r3)leads to a gain of response to Perillartine. The dose-response curve show the efficacy of responses of theTas1r2 subunits among species: hTAS1R2rhTas1r2smTas1r2mTas1r2. These results demonstrate thatthe monomeric Tas1r2 subunit can be activated by Perillartine in a species-dependent manner 1.REFE

6、RENCES1. Cai C, et al. Characterization of the Sweet Taste Receptor Tas1r2 from an Old World Monkey Species Rhesus Monkey and Species-Dependent Activation of the Monomeric Receptor by an Intense SweetenerPerillartine. PLoS One. 2016 Aug 1;11(8):e0160079.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-