医学免疫学英文版教学课件：Chapter 17 immunoregulation

1、Chapter 17 Immune regulationImmunoregulation is an immunological process by which the immune response is restrained or controlled. A number of different aspects contribute to this process, including molecules, immunocytes and nerve system /endocrine systemContentGenetic control of immune responseMol

2、ecular immunoregulationCellular immunoregulationHolistic immunoregulationSection I Genetic control of immune responseGenes encode TCR and BCRGenes encode molecular regulating immune response: MHCSection II. Molecular immunoregualtionImmune regulation by antigenfeedback regulation by antibodyRegulati

3、on of ComplementRegulation of co-stimulator and receptor1. Immune regulation by antigen Administered route of Ag subcutaneous strong immune response oral tolerance Dosage of AgCharacteristic of antigen structure antigen competition2. Regulation of antibodyRegulation of immune complex: IgM, IgGRegula

4、tion of idotype-anti-idiotype network1) Regulation of immune complex Ig M up regulate immune response by CD21 IgG down regulate immune response by FcrRII Antibody feedback regulationFcrR IIBCR BCR Antibody Feedback Inhibition ITIMAgAgantibody feedback inhibition:antibody feedback inhibition:The down

5、regulation of antibody production by secreted antibody that occurs when antigen-antibody complexes simultaneously engage B cell membrane Ig and Fc receptor (FcRII). Under these conditions, the cytoplasmic tails of the Fc receptors transduce inhibitory signals inside the B cell2) The idiotype network

6、s and immunologic regulationIdiotopic determinant or idiotype (Id): a unique determinant on an antibody or TCR molecule, usually formed by one or more of the hypervariable regions.Idiotopic determinant may be recognized as “foreign” in an individual but they are usually present in quantities too low

7、 to induce self-tolerance.anti-idiotypic antibody (or TCR) (AId): antibodies against idiotype of antibodies or TCRsAb2Ab2YYBInternal imageAb2Ab2YYBInternal imageAb3: internal image of Ab13.regulation by activated complement fragmentsPromote APC capture antigens: CR1 receptor on APC capture C3b-Ag-Ab

8、 complex2) Promote the activation of B cell CR2 on B cell4. Regulation of co-stimulator and receptorT cell: B7 - CD28, CTLA-4B cell: CD40L - CD40, FcRB5. Regulation of cytokinesActive receptor and inhibitory receptor on immunocyteImmunocyte active receptor inhibitory receptor B cell BCR FcRII-B T ce

9、ll TCR,CD28 CTLA-4 NK cell CD94/NKG2C CD94/NKG2A KIR2DS KIR2DL KIR3DS KIR3DL NCR,NKG2D Mast cell FcR1 FcRII-B B 细胞抑制性受体Section III Cellular immune regulationI. Regulation by T cell subsetsII. AICD (activation-induced cell death)1. T cellsCD4+CD25+ T regulatory cell: negative regulationTh1 and Th2 ce

10、ll Th1 helps Tc Th2 helps B cells (provide costimulatory molecles and cytokines)2. activation-induced cell death（AICD）：activated T or B cell apoptosis elicited by Fas (CD95) Fas is expressed on activated TcFasL on activated T cell binds to Fas on activated T cell and then induces T cell apoptosis.Section IV Regulation on systemic levelRegulation of nerve-endocrine-immune system networks: Nerve and endocrine regulate immune system. Immune system regulate nerve and endocrine system.神经肽免疫介质内分泌激素中枢神经系统松果体激素免疫系统免疫介