Doramectin - Parasite 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDoramectinCat. No.: HY-17035CAS No.: 117704-25-3分式: CHO分量: 899.11作靶点: Parasite作通路: Anti-infection储存式: -20C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据体外实验 DMSO : 50 mg/mL (55.61 mM)*

2、means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.1122 mL 5.5611 mL 11.1221 mL5 mM 0.2224 mL 1.1122 mL 2.2244 mL10 mM 0.1112 mL 0.5561 mL 1.1122 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作

3、液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (2.78 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (2.78 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂

4、师www.MedChemE物活性 Doramectin具有抗寄活性。REFERENCES1. Davey RB, Pound JM, Klavons JA, Lohmeyer KH, Freeman JM, Olafson PU.Analysis of doramectin in the serum of repeatedly treatedpastured cattle used to predict the probability of cattle fever ticks (Acari: Ixodidae) feeding to repletion.Exp Appl Acarol. 20

5、12 Apr;56(4):365-74. doi: 10.1007/s10493-012-9525-1.2. Wang XJ, Zhang J, Wang JD, Huang SX, Chen YH, Liu CX, Xiang WS.Four new doramectin congeners with acaricidal and insecticidalactivity from Streptomyces avermitilis NEAU1069.Chem Biodivers. 2011 Nov;8(11):2117-25. doi: 10.1002/cbdv.201000295.3. S

6、arre C, Claerebout E, Vercruysse J, Levecke B, Geldhof P, Pardon B, Alvinerie M, Sutra JF, Geurden T.Doramectin resistance inHaemonchus contortus on an alpaca farm in Belgium.Vet Parasitol. 2012 Apr 30;185(2-4):346-51.4. Lobetti R.Successful resolution of oesophageal spirocercosis in 20 dogs followi

7、ng daily treatment with oral doramectin.Vet J. 2012Jul;193(1):277-8.5. Wang JB, Pan HX, Tang GL.Production of doramectin by rational engineering of the avermectin biosynthetic pathway.Bioorg Med ChemLett. 2011 Jun 1;21(11):3320-3.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use