MP-A08 - SPHK 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMP-A08Cat. No.: HY-19794CAS No.: 219832-49-2分式: CHNOS分量: 519.64作靶点: SPHK作通路: Immunology/Inflammation储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (96.22 mM)H2O : 40% PEG300 5% Tw

2、een-80 45% salineSolubility: 2.5 mg/mL (4.81 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (4.81 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 MP-A08个度选择性的 ATP 竞争性的 SPHK1 抑制剂。体外研究 MP-A08 blocks pro-proliferative signalling pa

3、thways, induces mitochondrial-associated apoptosis in a SK-dependent manner, and reduces the growth of human lung adenocarcinoma tumours in a mouse xenograftmodel by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis. MP-A08 inhibit SphK2,cause a decrease in EC barrier integrity

4、in vitro in both cell type.2体内研究 MP-A08 suppresses the growth of human lung tumor xenografts in mice.REFERENCES1. Pitman MR et al. A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget, 2015 Mar30, 6(9):7065-83.2. Dimasi DP et al. Examining the Role of Sphingosine Kinase-2 in the Regulation of Endothelial Cell Barrier Integrity. Microcirculation,2016 Apr, 23(3):248-65.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>