PD173955 - Bcr-Abl 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPD173955Cat. No.: HY-10395CAS No.: 260415-63-2分式: CHClNOS分量: 443.35作靶点: Bcr-Abl; Src作通路: Protein Tyrosine Kinase/RTK储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 32 mg/mL (72.18 mM)* mean

2、s soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.2556 mL 11.2778 mL 22.5555 mL5 mM 0.4511 mL 2.2556 mL 4.5111 mL10 mM 0.2256 mL 1.1278 mL 2.2556 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 PD173955是Src激酶家族选择性抑制剂，对Src、Yes和Abl激酶IC50值约为22nM

3、，对FGFR_alpha_抑制性弱，对InsR和PKC活性。户使本产品发表的科研献1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE Technical University of Munich. 24.01.2018.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Moasser MM, et al. Inhibition of Src kinases by a selective tyrosine kinase inhibitor causes mit

4、otic arrest. Cancer Res. 1999 Dec15;59(24):6145-52.2. Kraus GA, et al. New effective inhibitors of the Abelson kinase. Bioorg Med Chem. 2010 Sep 1;18(17):6316-21.3. Windham TC, et al. Src activation regulates anoikis in human colon tumor cell lines. Oncogene. 2002 Nov 7;21(51):7797-807.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 0