Tyr-Gly-Gly-Phe-Met-OH-Met-Enkephalin-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETyr-Gly-Gly-Phe-Met-OHCat. No.: HY-P0073CAS No.: 58569-55-4Synonyms: Met-Enkephalin; Methionine enkephalin分式: CHNOS分量: 573.66Sequence: Tyr-Gly-Gly-Phe-MetSequence Shortening: YGGFM作靶点: Opioid Receptor作通路: GPCR/G Protein; Neurona

2、l Signaling储存式: Powder -80C 2 years-20C 1 yearIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 40 mg/mL (69.73 mM)H2O : 6.67 mg/mL (11.63 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.7432 mL 8.7160 mL 17.4319 mL5 mM 0.3486 mL 1.

3、7432 mL 3.4864 mL10 mM 0.1743 mL 0.8716 mL 1.7432 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Tyr-Gly-Gly-Phe-Met-OH 通过结合阿样物质受体 (opioid receptor)，可调控类免疫功能，抑制肿瘤长。1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEIC50 & Target Opioid Receptor 1.体外研究 Methionine enkephalin (MENK)

4、, an endogenous neuropeptide has a crucial role in both neuroendocrine andimmune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activityby binding to the opioid receptors on immune and cancer cells. MENK may also change the tumormicroenvironment by binding t

5、o opioid receptor on or in cancer cells. All of these mechanisms of action havebiologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationshipbetween the endocrine and immune systems 1.REFERENCES1. Zhao D, et al. Methionine enkephalin, its role in immunoregulation and cancer therapy. Int Immunopharmacol. 2016 Feb 23. pii: S1567-5769(16)30050-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792