Cyclophosphamide-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECyclophosphamideCat. No.: HY-17420CAS No.: 50-18-0分式: CHClNOP分量: 261.09作靶点: DNA Alkylator/Crosslinker作通路: Cell Cycle/DNA Damage储存式: 4C, protect from light* 该产品在溶液状态不稳定，建议您现现配，即刻使。溶解性数据体外实验 H2O : 55 mg/mL (210.66 mM)DMSO : 38 mg/

2、mL (145.54 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.8301 mL 19.1505 mL 38.3010 mL5 mM 0.7660 mL 3.8301 mL 7.6602 mL10 mM 0.3830 mL 1.9150 mL 3.8301 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现现配，即刻使。BIOLOGICAL ACTIVITY物活性 Cyclophosphamide种合成的

3、 DNA Alkylator，在化学上与氮芥类有关，具有抗肿瘤及免疫抑制活性。IC50 & Target DNA Alkylator 1体外研究Cyclophosphamide induces outer membrane blebbing, leads to DNA fragmentation, as revealed by TUNELstaining of free 3-OH DNA ends, and induces cleavage of the caspase 3 and caspase 7 substrate PARP in1/2 Master of Small Molecules

4、 您边的抑制剂师www.MedChemE9L/P450 cells. Bcl-2 expression fully blocks the activation of both initiator caspases as well as the effectorcaspase 3 in cells treated with activated Cyclophosphamide. Bcl-2 inhibits the cytotoxic effects but not thecytostatic effects of activated Cyclophosphamide 1. Cyclophosp

5、hamide inhibits the AChE reversibly with anIC50 of 511 M 2. Carbon tetrachloride does not affect the direct cytotoxicity of cyclophosphamide or 4-hydroxycyclophosphamide to cells in culture 3.体内研究 Cyclophosphamide (injected i.p.;2mg/mouse in 0.1 mL PBS, in C3H mice bearing SW1 tumors) increases thep

6、ercentage of cells that stained for CD3, CD4 or CD8 in both spleens and tumors 4.Animal Model: Six to eight-week old female C3H/HeN mice bearing SW1 tumors 4Dosage: 2 mg/mouseAdministration: Injected i.p.; 2mg/mouse in 0.1 mL PBS; 4 daysResult: Increased the percentage of cells that stained for CD3,

7、 CD4 or CD8 in both spleens andtumors.户使本产品发表的科研献 J Mol Med (Berl). 2019 Jun 14.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Schwartz PS, et al. Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol Pharmacol. 2001Dec;60(6):1268-1279.2. al-Jafari AA,

8、et al. Inhibition of human acetylcholinesterase by cyclophosphamide. Toxicology. 1995 Jan 19;96(1):1-6.3. Harris RN, et al. Carbon tetrachloride-induced increase in the antitumor activity of cyclophosphamide in mice: a pharmacokineticstudy.Cancer Chemother Pharmacol. 1984;12(3):167-72.4. Liu P, et al. Administration of cyclophosphamide changes the immune profile of tumor-bearing mice. J Immunother. 2010 Jan;33(1):53-9.McePdfHeightCaution: Product has not been fully validated for medical applic