Phe-Met-Arg-Phe-amide-trifluoroacetate - Potassium Channel Activator - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPhe-Met-Arg-Phe amide trifluoroacetateCat. No.: HY-P0249ACAS No.: 159237-99-7分式: CHFNOS分量: 826.81Sequence: Phe-Met-Arg-Phe-NH2Sequence Shortening: FMRF-NH2作靶点: Potassium Channel作通路: Membrane Transporter/Ion Channel储存式: Powder -8

2、0C 2 years-20C 1 yearIn solvent -80C 6 months-20C 1 monthBIOLOGICAL ACTIVITY物活性 Phe-Met-Arg-Phe amide trifluoroacetate种神经肽，在肽能神经元中激活 K+ 电流，ED50 为 23 nM，这种作具有剂量依赖性。IC50 & Target ED50: 23 nM (K+ current) 1体外研究 In the molluscan central nervous system, Phe-Met-Arg-Phe amide (FMRFa) acts on K+ channels i

3、n sensory,motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe amide activates a novel K+ current that ischaracterized by a combined voltage- and receptor-dependent gating mechanism, with both factors beingnecessary for opening of the channels 1. Phe-Met-Arg-Phe amide (1 M) significantly inhibits gl

4、ucosestimulated (300 mg/dL) insulin release (p 2.体内研究 Phe-Met-Arg-Phe amide (FMRFamide) stimulates growth hormone secretion in conscious OVX rats. Thepresence of Phe-Met-Arg-Phe amide-like immunoreactivity in neuronal elements in the hypothalamussuggested a role for this in the hypothalamic control

5、of the anterior pituitary function. The injection of 200 ng(313.8 picomoles) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min afterinjection. The GH-increasing effect of 400-800 ng (627-1255 picomoles) of FMRFamide is already developedafter 5 min and lasted up to 30 min 3.1

6、/2 Master of Small Molecules 您边的抑制剂师www.MedChemEREFERENCES1. Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscanneurones. J Gen Physiol. 1997 Nov;110(5):611-28.2. Sorenson RL, et al. Phe-met-arg-phe-amide (FMRF-NH2) inhibits

7、 insulin and somatostatin secretion and anti-FMRF-NH2 sera detectspancreatic polypeptide cells in the rat islet. Peptides. 1984 Jul-Aug;5(4):777-82.3. Ottlecz A, et al. Phe-Met-Arg-Phe-amide (FMRFamide) stimulated growth hormone secretion in conscious OVX rats. Neuropeptides.1987 Feb-Mar;9(2):161-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research u