AM-92016-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAM-92016 hydrochlorideCat. No.: HY-101253CAS No.: 133229-11-5分式: CHClNOS分量: 483.84作靶点: Others作通路: Others储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据体外实验 DMSO : 260 mg/mL (537.3

2、7 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.0668 mL 10.3340 mL 20.6680 mL5 mM 0.4134 mL 2.0668 mL 4.1336 mL10 mM 0.2067 mL 1.0334 mL 2.0668 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清

3、的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (4.48 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.17 mg/mL (4.48 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.17 mg

4、/mL (4.48 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 AM 92016 (hydrochloride)种特异性 IK 抑制剂。AM 92016 (hydrochloride) 延迟整流钾通道 (IK)，使膜复极化从限制神经冲动的持续时间。 AM 92016 (hydrochloride) 延长了豚和兔分离的室细胞的脏动作电位持续时间，IC50 值为 30 nM。REFERENCES1. ConnorsSP,etal.Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbitventricular cells. Br JPharmacol. 1992 Aug;106(4):958-65.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>