R-minus-Rolipram-R-Rolipram-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE(R)-(-)-RolipramCat. No.: HY-16900ACAS No.: 85416-75-7Synonyms: (R)-Rolipram; (-)-Rolipram分式: CHNO分量: 275.34作靶点: Phosphodiesterase (PDE)作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C

2、 1 month溶解性数据体外实验 DMSO : 49 mg/mL (177.96 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.6319 mL 18.1594 mL 36.3187 mL5 mM 0.7264 mL 3.6319 mL 7.2637 mL10 mM 0.3632 mL 1.8159 mL 3.6319 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物

3、活性 (R)-(-)-RolipramcAMP-特异的PDE4抑制剂，IC50为220nM。在抑制PDE4膜结合实验中其抑制性于(+)-rolipram 2.5倍。体外研究The increase of cAMP synthesis with the adenylate cyclase activator forskolin or the decrease of cAMPhydrolysis by the phosphodiesterase inhibitors Isobutylmethylxanthine (IBMX) and (R)-(-)-Rolipram1/2 Master of Sm

4、all Molecules 您边的抑制剂师www.MedChemE(MedChem Express) suppresses caspase-1 cleavage and IL-1 secretion in a dose-dependent manner 1.户使本产品发表的科研献 Immunity. 2016 Oct 18;45(4):944. Patent. US20180263995A1.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct18;45(4):944.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>