VX-222-VCH-222-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEVX-222Cat. No.: HY-75800CAS No.: 1026785-59-0Synonyms: VCH-222分式: CHNOS分量: 445.61作靶点: HCV; HCV Protease作通路: Anti-infection; Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验

2、 DMSO : 32 mg/mL (71.81 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.2441 mL 11.2206 mL 22.4411 mL5 mM 0.4488 mL 2.2441 mL 4.4882 mL10 mM 0.2244 mL 1.1221 mL 2.2441 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 VX-222 (VCH-222

3、)是新型的HCV聚合酶选择性抑制剂，对NS5B 1a和NS5B 1b的IC50分别为0.94和1.2 M。户使本产品发表的科研献1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE Antivir Res. 2019 Jul. J Virol Methods. 2019 Apr 17. pii: S0166-0934(18)30293-3.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Yi G, Deval J, Fan B, Cai H, Soulard

4、 C, Ranjith-Kumar CT, Smith DB, Blatt L, Beigelman L, Kao CC.Biochemical study of thecomparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.Antimicrob Agents Chemother. 2012 Feb;56(2):830-7.Epub 2011 Dec 5.2. Godzik P, Komorowski M, Cielecka-Kuszyk J, Madaliski K.Inhibito

5、rs of hepatitis C virus-current standards and status ofinvestigations.Przegl Epidemiol. 2010;64(4):473-8.3. M. Rodriguez-Torres et al. SAFETY AND ANTIVIRAL ACTIVITY OF THE HCV NON-NUCLEOSIDE POLYMERASE INHIBITOR VX-222IN TREATMENT-NAIVE GENOTYPE 1 HCV-INFECTED PATIENTS Journal of Hepatology Volume 52, Supplement 1 , Page S14, April2010McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0