BG45 - HDAC 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBG45Cat. No.: HY-18712CAS No.: 926259-99-6分式: CHNO分量: 214.22作靶点: HDAC作通路: Cell Cycle/DNA Damage; Epigenetics储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 48 mg/mL (224.07 mM)* means solub

2、le, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.6681 mL 23.3405 mL 46.6810 mL5 mM 0.9336 mL 4.6681 mL 9.3362 mL10 mM 0.4668 mL 2.3340 mL 4.6681 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 BG45 is diluted in natural saline (NS)2.BIOLOGICAL ACTIVITY物活性 BG45个HDAC

3、I型抑制剂, 选择性抑制HDAC3 (IC50=289 nM). BG45抑制HDAC1/2/ 6, 效降低 (IC50分别为2, 2.2, 和 20M)。IC50 & Target HDAC3 HDAC1 HDAC21/2 Master of Small Molecules 您边的抑制剂师www.MedChemE0.289 M (IC50) 2.0 M (IC50) 2.2 M (IC50)户使本产品发表的科研献 J Mol Med (Berl). 2019 Jun 14. Oncol Rep. 2018 Apr;39(4):1957-1965.See more customer valid

4、ations on HYPERLINK / www.MedChemEREFERENCES1. Iaconelli J, et al. HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of -Catenin in Human iPSC-DerivedNeuronal Cells. ACS Chemical Biology (2015), 10(3), 883-890.2. Tang D, et al. Metformin facilitates BG45-induced apoptosis via an anti-Warburg effect in cholangiocarcinoma cells. Oncol Rep. 2018Apr;39(4):1957-1965.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;F