GSK3326595-EPZ015938-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGSK3326595Cat. No.: HY-101563CAS No.: 1616392-22-3Synonyms: EPZ015938分式: CHNO分量: 452.55作靶点: Histone Methyltransferase作通路: Epigenetics储存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 30 mg/mL (66.29 mM

2、)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.2097 mL 11.0485 mL 22.0970 mL5 mM 0.4419 mL 2.2097 mL 4.4194 mL10 mM 0.2210 mL 1.1049 mL 2.2097 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实

3、验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (4.80 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.17 mg/mL (4.80 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1

4、/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.17 mg/mL (4.80 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 GSK3326595种有效的，选择性的，可逆的蛋精氨酸甲 转移酶5 (PRMT5) 抑制剂，具有泛的抗增殖活性。IC50 & Target IC50: 6.2 nM (PRMT5) 1体外研究 GSK3326595 (EPZ015938), has entered clinical trials for the treatment of solid tumors and non-Hodgkinslymphoma 1.REFERENCES1. WO 2016022605 A1McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fa