胃癌免疫治疗课件

1、激活免疫 重燃希望胃癌的免疫治疗NP/NIV/4592/03/20/20-03/20/22免疫治疗的作用机理晚期胃癌进入免疫治疗新时代免疫治疗的疗效特征与安全性NP/NIV/4592/03/20/20-03/20/22NP/NIV/4592/03/20/20-03/20/22晚期胃癌的治疗现状仍有待改善NP/NIV/4592/03/20/20-03/20/22免疫治疗：晚期胃癌患者新的治疗选择免疫治疗通过激发或增强机体的免疫功能，控制和杀伤癌细胞。代表性药物为免疫检查点抑制剂PD-1单抗1.Couzin-Frankel J. Science. 2013 Dec 20;342(6165):143

2、2-3.2./advocacy-policy/asco-in-action/asco-names-cancer-advance-year3./advocacy-policy/asco-in-action/capitol-hill-asco-announces-advance-year-urges-congress-fund-cancer4.https:/prizes/medicine/2018/summaryNP/NIV/4592/03/20/20-03/20/22NP/NIV/4592/03/20/20-03/20/22免疫治疗的作用机理晚期胃癌进入免疫治疗新时代免疫治疗的疗效特征与安全性N

3、P/NIV/4592/03/20/20-03/20/22NP/NIV/4592/03/20/20-03/20/22NP/NIV/4592/03/20/20-03/20/22NP/NIV/4592/03/20/20-03/20/22NP/NIV/4592/03/20/20-03/20/22NP/NIV/4592/03/20/20-03/20/22NP/NIV/4592/03/20/20-03/20/22NP/NIV/4592/03/20/20-03/20/22NP/NIV/4592/03/20/20-03/20/22NP/NIV/4592/03/20/20-03/20/22NP/NIV/4592

4、/03/20/20-03/20/22NP/NIV/4592/03/20/20-03/20/22免疫治疗的作用机理晚期胃癌进入免疫治疗新时代免疫治疗的疗效特征与安全性NP/NIV/4592/03/20/20-03/20/22免疫治疗疗效特征1：作用持久1. Chen DS, et al. Immunity. 2013;39(1):1-10. 2. Kaech SM, et al. Nat Rev Immunol. 2012;12(11) : 749-61.抗肿瘤免疫循环不断重复：持续识别和记忆肿瘤抗原，并随时间推移不断增强和扩大1。免疫记忆：一些T细胞分化为成熟记忆T细胞，提供长期免疫记忆保护2

5、。NP/NIV/4592/03/20/20-03/20/22免疫治疗疗效特征2：可能存在假性进展NP/NIV/4592/03/20/20-03/20/22免疫相关不良反应以皮肤和胃肠道最为常见Immunotherapy-related side effects and their management An ESMO guide for patients,NP/NIV/4592/03/20/20-03/20/221. Davies M, et al. Immunotargets Ther. 2017;6:51-71; 2. Amos SM, et al. Blood. 2011; 118(3): 499-509早发现，早处理，免疫相关不良反应通常可逆NP/NIV/4592/03/20/20-03/20/22以免疫检查点抑制剂为代表的免疫治疗开启晚期胃癌治疗新时代免疫治疗作用机制独特，有别于传统化疗及靶向治疗等在免疫治疗期间或结束应加强监测，