Brincidofovir-CMX001-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBrincidofovirCat. No.: HY-14532CAS No.: 444805-28-1Synonyms: CMX001; HDP-CDV分式: CHNOP分量: 561.69作靶点: CMV作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 1 mg/mL (1.78 mM; a

2、djust pH to 8 with NaOH and heat to 50C)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.7803 mL 8.9017 mL 17.8034 mL5 mM - - -10 mM - - -请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Brincidofovir (CMX001; HDP-CDV)种具有服活性的Cidofovir (CDV) 亲脂形式，对某些疱疹病毒，腺病毒和正痘病毒，CDV具有更强的体内外活性。I

3、C50 & Target EC50: 5.5 nM (anti-CMV, in PDA at 7 dpi)REFERENCES1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE1. Parker S, et al. Efficacy of therapeutic intervention with an oral ether-lipid analogue of cidofovir (CMX001) in a lethal mousepox model.Antiviral Res. 2008 Jan;77(1):39-49.2. Quenelle

4、DC, et al. Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distributionstudies. JInfect Dis. 2010 Nov 15;202(10):1492-9.3. Gosert R, et al. CMX001 (1-O-hexadecyloxypropyl-cidofovir) inhibits polyomavirus JC replication in human brain progenitor-derivedas

5、trocytes. Antimicrob Agents Chemother. 2011 May;55(5):2129-36.4. Marty FM, et al. CMX001 to prevent cytomegalovirus disease in hematopoietic-cell transplantation. N Engl J Med. 2013 Sep26;369(13):1227-36.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5895