Boc-MLF-TFA-Boc-Met-Leu-Phe-OH-TFA-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBoc-MLF TFACat. No.: HY-103473ASynonyms: Boc-Met-Leu-Phe-OH (TFA)分式: CHFNOS分量: 623.68作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 150 mg/mL (240.51 mM; Need ultraso

2、nic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.6034 mL 8.0169 mL 16.0339 mL5 mM 0.3207 mL 1.6034 mL 3.2068 mL10 mM 0.1603 mL 0.8017 mL 1.6034 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以

3、下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.01 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (4.01 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (4.01 mM); Clear s

4、olution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Boc-MLF (TFA)种多肽，为甲酰肽受体 (formyl peptide receptor (FPR) 拮抗剂，在浓度下，对甲酰肽样受体 1 FPRL1 也具有拮抗作。IC50 & Target FPR/FPRL1 1体外研究 Boc-MLF inhibits superoxide production induced by FPR agonist fMLF, with an EC50 of 630 nM inneutrophils

5、 1.Boc-MLF (25 M) blocks FPRL1-agonist serum amyloid A (SAA) induced calcium response 1.REFERENCES1. Stenfeldt AL, et al. Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formylpeptide receptor. Inflammation. 2007 Dec;30(6):224-9. Epub 2007 Aug 9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02