Bexarotene-LGD1069-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBexaroteneCat. No.: HY-14171CAS No.: 153559-49-0Synonyms: LGD1069分式: CHO分量: 348.48作靶点: RAR/RXR; Autophagy作通路: Metabolic Enzyme/Protease; Autophagy储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DM

2、SO : 60 mg/mL (172.18 mM; Need ultrasonic)H2O : 90% corn oilSolubility: 2.08 mg/mL (5.97 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Bexarotene (LGD1069)于治疗肤T细胞淋巴瘤的选择性类视黄醇X受体 (retinoid X receptors (RXR) 激动剂。户使本产品发表的科研献 Cell. 2018 Aug 9;174(4):843-855.e1

3、9. Cell Physiol Biochem. 2016;40(5):1239-1251. J Pain. 2019 Jan 17. pii: S1526-5900(18)30607-2. Neurobiol Dis. 2018 Sep;117:114-124. Int J Mol Sci. 2019 Apr 11;20(7). pii: E1801.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Vakeva L, Ranki A, Hahtola S.Ten-year experience of

4、bexarotene therapy for cutaneous T-cell lymphoma in Finland.Acta DermVenereol. 2012 May;92(3):258-63. doi: 10.2340/00015555-1359.2. Zhang X, Schlaak M, Fabri M, Mauch C, Kurschat P.Successful Treatment of a Panniculitis-Like Primary Cutaneous T-Cell Lymphomaof the / Type with Bexarotene.Case Rep Der

5、matol. 2012 Jan;4(1):56-60.3. Orendas P, Kubatka P, Kajo K, Stollarova N, Kassayova M, Bojkova B, Pec M, Nosal V, Kiskova T, Zihlavnikova K, KarsnakovaR.Melatonin enhanced bexarotene efficacy in experimental mammary carcinogenesis.Neoplasma. 2012;59(4):469-74.4. Cras A, Politis B, Balitrand N, Darsi

6、n-Bettinger D, Boelle PY, Cassinat B, Toubert ME, Chomienne C.Bexarotene via CBP/p300 inducessuppression of NF-B-dependent cell growth and invasion in thyroid cancer.Clin Cancer Res. 2012 Jan 15;18(2):442-53.5. Gui Y, et al. Bexarotent attenuated CCI-induced spinal neuroinflammation and neuropathic pain by targeting MKP-1. J Pain. 2019 Jan17. pii: S1526-5900(18)30607-2.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel