H-Val-Pro-Pro-OH-TFA - Angiotensin Receptor 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEH-Val-Pro-Pro-OH TFACat. No.: HY-114161A分式: CHFNO分量: 425.4作靶点: Angiotensin Receptor作通路: GPCR/G Protein储存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 160 mg/mL (376.12 mM)* means soluble, but saturati

2、on unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.3507 mL 11.7536 mL 23.5073 mL5 mM 0.4701 mL 2.3507 mL 4.7015 mL10 mM 0.2351 mL 1.1754 mL 2.3507 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 H-Val-Pro-Pro-OH (TFA)，奶来 的脯氨酸肽衍物， 管紧张素 I 转化酶 (ACE) 的抑制剂，其IC50 为 9M。IC5

3、0 & Target IC50: 9 M (ACE) 1.体外研究H-Val-Pro-Pro-OH (TFA), a proline peptides derivative, could inhibit Angiotensin I converting enzyme (ACE),with an IC50 of 9 M 1. H-Val-Pro-Pro-OH (TFA) could enhance insulin sensitivity and prevent insulinresistance in 3T3-F442A pre-adipocytes. H-Val-Pro-Pro-OH (TFA

4、) also has anti-hypertensive and anti-inflammatory functions. H-Val-Pro-Pro-OH (TFA) further enhances the expression of glucose transporter 41/2 Master of Small Molecules 您边的抑制剂师www.MedChemE(GLUT4) in adipocytes and restores glucose uptake in TNF-treated adipocytes 2.REFERENCES1. Nakamura Y, et al.

5、Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995Apr;78(4):777-83.2. Chakrabarti S, et al. Milk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance Insulin Sensitivity and Prevent InsulinResistance in 3T3-F442A Preadipocytes. J Agric Food Chem. 2018 Oct 3;66(39):10179-10187.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;