Mutant-IDH1-IN-1 - Isocitrate Dehydrogenase (IDH) 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMutant IDH1-IN-1Cat. No.: HY-12475CAS No.: 1355326-21-4分式: CHFNO分量: 498.59作靶点: Isocitrate Dehydrogenase (IDH)作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 45

2、 mg/mL (90.25 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.0057 mL 10.0283 mL 20.0566 mL5 mM 0.4011 mL 2.0057 mL 4.0113 mL10 mM 0.2006 mL 1.0028 mL 2.0057 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Mutant IDH1-IN-1IDH1 突变体的

3、选择性抑制剂，对突变体IDH1 R132C/R132C，IDH1R132H/R132H，IDH1 R132H/WT和野型IDH1的 IC50 值分别为4, 42, 80 和 143 nM。IC50 & Target IC50: 4 nM (IDH1 R132C/R132C), 42 nM (IDH1 R132H/R132H), 80 nM (IDH1 R132H/WT), 143 nM (IDH1wild type) 11/2 Master of Small Molecules 您边的抑制剂师www.MedChemE户使本产品发表的科研献 Sci Rep. 2017 Oct 6;7(1):12

4、758.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Deng G, et al. Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allostericsmall molecule. J Biol Chem. 2015 Jan 9;290(2):762-74.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 02