NT157-Tyrphostin-NT157-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENT157Cat. No.: HY-100037CAS No.: 1384426-12-3Synonyms: Tyrphostin NT157分式: CHBrNOS分量: 412.26作靶点: Insulin Receptor作通路: Protein Tyrosine Kinase/RTK储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMS

2、O : 30 mg/mL (72.77 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.4257 mL 12.1283 mL 24.2565 mL5 mM 0.4851 mL 2.4257 mL 4.8513 mL10 mM 0.2426 mL 1.2128 mL 2.4257 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 NT157 is dissolved in 20% 2-hydroxypr

3、opyl-cyclodextrin (2-HP-CD)3.BIOLOGICAL ACTIVITY物活性 NT157种选择性的IRS-1/2抑制剂IC50 为 0.3 到0.8 M。1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE户使本产品发表的科研献 Nat Commun. 2018 Jul 4;9(1):2611.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Garofalo C, et al. Preclinical Effectiveness o

4、f Selective Inhibitor of IRS-1/2 NT157 in Osteosarcoma Cell Lines. Front Endocrinol(Lausanne). 2015 May 13;6:74.2. Ibuki N, et al. The tyrphostin NT157 suppresses insulin receptor substrates and augments therapeutic response of prostate cancer. MolCancer Ther. 2014 Dec;13(12):2827-39.3. Ishii H, et al. miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved hostimmunity. Nat Commun. 2018 Jul 4;9(1):2611.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589559