Danshensu-Dan-shen-suan-A-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDanshensuCat. No.: HY-N1913CAS No.: 76822-21-4Synonyms: Dan shen suan A; Salvianic acid A分式: CHO分量: 198.17作靶点: Keap1-Nrf2; Autophagy作通路: NF-B; Autophagy储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体

2、外实验 H2O : 6.2 mg/mL (31.29 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 5.0462 mL 25.2309 mL 50.4617 mL5 mM 1.0092 mL 5.0462 mL 10.0923 mL10 mM 0.5046 mL 2.5231 mL 5.0462 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Danshensu丹参的有效成分，能够激活

3、Nrf2 信号通路，保护管。体外研究Danshensu (DSS) significantly decreases the level of the marker enzymes (creatine kinase and lactatedehydrogenase) from the coronary effluents and myocardial infarction size. This could markedly contribute tothe recovery of cardiac function after I/R injury. DSS also has ROS scaven

4、ging activity and boostsendogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEerythroid-2-related factor 2 (Nrf2) signaling pathway which is mediated by Akt and ERK1/2 in western blotanalysis 2.体内研究 Acut

5、e treatment with a single dose of danshensu in rats with normal tHcy does not change plasma tHcy. Incontrast, danshensu significantly lowers tHcy in rats with elevated tHcy. The relatively higher cysteine andglutathione levels after treatment with danshensu indicates that its tHcy-lowering effect is

6、 via increasedactivity of the trans-sulphuration pathway 1.PROTOCOLAnimal All chemicals are dissolved in saline, except for tolcapone which is dissolved in saline containing 20% (v/v)Administration 1 PEG 200. During experiments, rats are fasted overnight and randomLy assigned into different groups.

7、About200 L blood is taken from orbital sinus alternatively after ethyl ether anaesthesia, and then the eye is quicklysterilized with alcohol and pressed with cotton. Blood samples are immediately collected into a polypropylenetube containing heparin-Na and centrifuged at 5000 g at 5C for 3 min. Prep

8、ared plasma samples are kept at20C and analysed within 48 h.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. YG Cao, et al. Beneficial effects of danshensu, an active component of Salvia miltiorrhiza, on homocysteine metabolism via the trans

9、-sulphuration pathway in rats. Br J Pharmacol. 2009 Jun; 157(3): 482490.2. Yu J, et al. Danshensu protects isolated heart against ischemia reperfusion injury through activation of Akt/ERK1/2/Nrf2 signaling. Int JClin Exp Med. 2015 Sep 15;8(9):14793-804.McePdfHeightCaution: Product has not been fully validated for medical