GCN2-IN-1-A-92-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGCN2-IN-1Cat. No.: HY-100877CAS No.: 1448693-69-3Synonyms: A-92分式: CHNO分量: 402.41作靶点: Ser/Thr Protease作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 60 mg/mL

2、(149.10 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.4850 mL 12.4251 mL 24.8503 mL5 mM 0.4970 mL 2.4850 mL 4.9701 mL10 mM 0.2485 mL 1.2425 mL 2.4850 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实

3、验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.21 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 GCN2-IN-1种有效的般性调控阻遏蛋激酶 2 (GCN2) 抑制剂，在酶和细胞检测中 IC50 都 0.3 M。IC50

4、 & Target IC50: 1体外研究 GCN2-IN-1 (Compound A-92) is a GCN2 inhibitor, which may be useful as a chemotherapeutic drug for thetreatment of cancer 1.REFERENCES1. Brazeau JF, et al. Triazolo4,5-dpyrimidine Derivatives as Inhibitors of GCN2. ACS Med Chem Lett. 2014 Feb 12;5(4):282-3.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 0