Lithocholic-acid-3α-Hydroxy-5β-cholanic-acid-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELithocholic acidCat. No.: HY-B0172CAS No.: 434-13-9Synonyms: 3-Hydroxy-5-cholanic acid分式: CHO分量: 376.57作靶点: Autophagy; Endogenous Metabolite作通路: Autophagy; Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -8

2、0C 6 months-20C 1 month溶解性数据体外实验 DMSO : 150 mg/mL (398.33 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.6555 mL 13.2777 mL 26.5555 mL5 mM 0.5311 mL 2.6555 mL 5.3111 mL10 mM 0.2656 mL 1.3278 mL 2.6555 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验

3、 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.64 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.64 mM); Clear soluti

4、on1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Lithocholic acid有毒的次级胆汁酸，能促使肝内胆汁淤积，能促进肿瘤发。IC50 & Target Human Endogenous Metabolite户使本产品发表的科研献 Cell Res. 2019 Mar;29(3):193-205. Br J Pharmacol. 2019 Jul;176(13):2162-2178. Sci Rep. 2017 Aug 30;7(1):9967. Food Chem Toxicol. 20

5、18 Jul 14;120:253-260.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Jenkins, D.J., et al., Effect on blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol. N Engl J Med, 1993.329(1): p. 21-6.2. Goldberg, A.A., et al., Lithocholic bile acid s

6、electively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget, 2011.2(10): p. 761-82.3. Matsubara, T., et al., TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. J Lipid Res, 2012. 53(12): p. 2698-707.4. Yang R, et al. Metabolomic analysis of cholestatic liver damage in mice. Food Chem Toxicol. 2018 Jul 14;120:253-260.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.T