Loureirin-A - Akt 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELoureirin ACat. No.: HY-N1505CAS No.: 119425-89-7分式: CHO分量: 286.32作靶点: Akt作通路: PI3K/Akt/mTOR储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 86.6 mg/mL (302.46 mM)* means soluble, but satura

2、tion unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.4926 mL 17.4630 mL 34.9260 mL5 mM 0.6985 mL 3.4926 mL 6.9852 mL10 mM 0.3493 mL 1.7463 mL 3.4926 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Loureirin A从龙树中分离到的 酮类物质，能够降低 Akt 的磷酸化，具有抗板聚集的作。IC50 & Target Akt体外研究

3、Loureirin A (50 M, 100 M) inhibits collagen-induced platelet ATP secretion and thrombin-stimulated P-selectin expression in a dose-dependent manner. Loureirin A also significantly impairs platelet spreading on1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEimmobilized fibrinogen. Loureirin A almost

4、 completely eliminates collagen-induced Akt phosphorylation atSer473 at the dose of 100 M, and has an additive inhibitory effect with the phosphoinositide 3-kinase (PI3K)inhibitor Ly294002 on collage-induced Akt phosphorylation in platelets at 50 M 1.REFERENCES1. Hao HZ, et al. Antiplatelet activity of loureirin A by attenuating Akt phosphorylation: In vitro studies. Eur J Pharmacol. 2015 Jan 5;746:63-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;