Pitavastatin-Calcium-NK-104-hemicalcium-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPitavastatin CalciumCat. No.: HY-B0144CAS No.: 147526-32-7Synonyms: NK-104 hemicalcium; Pitavastatin hemicalcium分式: CHFNO . / Ca分量: 440.49作靶点: HMG-CoA Reductase (HMGCR); Autophagy; Mitophagy作通路: Metabolic Enzyme/Protease; Autoph

2、agy储存式: 4C, protect from light, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight, stored under nitrogen)溶解性数据体外实验 DMSO : 50 mg/mL (113.51 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.2702 mL 11.3510 mL 22.7020 mL5

3、 mM 0.4540 mL 2.2702 mL 4.5404 mL10 mM 0.2270 mL 1.1351 mL 2.2702 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolub

4、ility: 2.5 mg/mL (5.68 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.68 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (5.68 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Pitavast

5、atin Calcium (NK-104 hemicalcium)有效的羟甲 戊酰-CoA (HMG-CoA) 还原酶抑制剂。Pitavastatin Calcium (NK-104 hemicalcium) 在HepG2细胞中抑制酸合成胆固醇的 IC50 为5.8 nM。REFERENCES1. Mukhtar RY, et al. Pitavastatin. Int J Clin Pract. 2005 Feb;59(2):239-52.2. Kajinami K, et al. Pitavastatin: efficacy and safety profiles of a novel synthetic HMG-CoA reductase inhibitor. Cardiovasc Drug Rev. 2003Fall;21(3):199-215.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;