NE-10790-3-PEHPC-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENE 10790Cat. No.: HY-16011CAS No.: 152831-36-2Synonyms: 3-PEHPC分式: CHNOP分量: 247.14作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 5 mg/mL (20.23 mM; ultrasonic and adju

2、st pH to 6 with NaOH)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.0463 mL 20.2314 mL 40.4629 mL5 mM 0.8093 mL 4.0463 mL 8.0926 mL10 mM 0.4046 mL 2.0231 mL 4.0463 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 NE 10790法尼焦磷酸 (FPP) 合成酶的弱抑制剂， 有效的磷酸利塞磷酸盐的磷酸酯类似物，也 种弱的抗吸收剂。IC5

3、0 & Target FPP synthase 1.体外研究NE 10790 inhibits incorporation of 14Cmevalonic acid into Rab6, but not into H-Ras or Rap1, proteins that1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEare modified by FTase and GGTase I, respectively. NE 10790 reduces viability in J774 cells. NE 10790prevents prenyla

4、tion of 22-26-kDa proteins that are not modified by FTase or GGTase I 1.REFERENCES1. Coxon FP, et al. Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically preventsRab prenylation in osteoclasts and macrophages. J Biol Chem. 2001 Dec 21;276(51):48213-22.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: