Resibufogenin-Bufogenin-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEResibufogeninCat. No.: HY-N0815CAS No.: 465-39-4Synonyms: Bufogenin; Recibufogenin分式: CHO分量: 384.51作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (260.07 mM

2、; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.6007 mL 13.0036 mL 26.0071 mL5 mM 0.5201 mL 2.6007 mL 5.2014 mL10 mM 0.2601 mL 1.3004 mL 2.6007 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可

3、以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (7.15 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.75 mg/mL (7.15 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Mole

4、cules 您边的抑制剂师www.MedChemESolubility: 2.75 mg/mL (7.15 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 酯蟾毒配(Resibufogenin) 华蟾素的种成分，具有抑制氧化应激及肿瘤再的功能。REFERENCES1. Hao S, et al. Effects of Resibufogenin and Cinobufagin on voltage-gated potassium channels in primary cultures of rat hippocampalneurons. Toxicol I

5、n Vitro. 2011 Dec;25(8):1644-53.2. Uddin MN, et al. Resibufogenin administration prevents oxidative stress in a rat model of human preeclampsia. Hypertens Pregnancy.2012;31(1):70-8.3. Ichikawa M, et al. Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human M

6、alignantTumor Cells. PLoS One. 2015 Jun 29;10(6):e0129851.4. Hao S, et al. Effects of resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons. Neurosci Lett. 2011 Aug26;501(2):112-6.5. Zheng J, et al. Novel microbial transformation of resibufogenin by Absidia coerules. Nat Prod Commun. 2011 Nov;6(11):1581-4.6. Xin XL, et al. Novel microbial transformation of resibufogenin by Fusarium solani. J Asian Nat Prod Res. 2011 Sep;13(9):831-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only