Ombitasvir-ABT-267-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOmbitasvirCat. No.: HY-13997CAS No.: 1258226-87-7Synonyms: ABT-267分式: CHNO分量: 894.11作靶点: HCV; HCV Protease作通路: Anti-infection; Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体

2、外实验 DMSO : 33 mg/mL (36.91 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.1184 mL 5.5922 mL 11.1843 mL5 mM 0.2237 mL 1.1184 mL 2.2369 mL10 mM 0.1118 mL 0.5592 mL 1.1184 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Ombitasvir种 H

3、CV NS5A 抑制剂，对 HCV基因型 1-5 和 6a 的 EC50 值分别为 0.82-19.3 pM 和 366 pM。IC50 & Target EC50: 0.82 to 19.3 pM (HCV genotypes 1 to 5), 366 pM (HCV genotype 6a) 1体外研究Ombitasvir is active against the genotype 2a JFH-1 replicon, with an EC50 of 0.82 pM, and the EC50s of1/2 Master of Small Molecules 您边的抑制剂师www.Med

4、ChemEombitasvir are 42 pM and 68 pM against the L28 and F28 variants of this genotype 6a replicon, respectively1. In GT1a, variants M28V, L31V, and H58D confers 58- to 243-fold resistance to Ombitasvir. Singlevariants M28T, Q30R, and Y93C/S confers 800- to 8965-fold resistance, while Y93H/N confers

5、40000-foldresistance to Ombitasvir 2.户使本产品发表的科研献 J Virol. 2018 Jan 2;92(2). pii: e01582-17. Antiviral Res. 2017 Mar;139:18-24. Chem Cent J. 2017 Jan 3;11:1. Xenobiotica. 2018 Nov 8:1-10. J Liq ChromaTogr R T. 2019 Mar.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Krishnan P,

6、et al. In vitro and in vivo antiviral activity and resistance profile of ombitasvir, an inhibitor of hepatitis C virus NS5A.Antimicrob Agents Chemother. 2015 Feb;59(2):979-872. DeGoey DA, et al. Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A. J Med Chem. 2014 Mar 13;57(5):2047-57McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 40