RS-Butyryltimolol-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE(RS)-ButyryltimololCat. No.: HY-102032A分式: CHNOS分量: 386.51作靶点: Adrenergic Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Pure form -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (258.73

2、 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.5873 mL 12.9363 mL 25.8726 mL5 mM 0.5175 mL 2.5873 mL 5.1745 mL10 mM 0.2587 mL 1.2936 mL 2.5873 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的

3、储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 5 mg/mL (12.94 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 5 mg/mL (12.94 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 5 mg/mL (12.

4、94 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 (RS)-ButyryltimololButyryltimolol 的外消旋体。Butyryltimolol Timolol 的丁酸酯。Timolol 选择性 肾上腺素受体阻滞剂。REFERENCES1. Chang SC, et al. Relative effectiveness of prodrug and viscous solution approaches in maximizing the ra

5、tio of ocular to systemicabsorption of topically applied timolol. Exp Eye Res. 1988 Jan;46(1):59-69.2. Lerner SF, et al. Efficacy and Tolerability of Travoprost 0.004%/Timolol 0.5% Fixed-Dose Combination for the Treatment of PrimaryOpen-Angle Glaucoma or Ocular Hypertension Inadequately Controlled with Beta-Blocker Monotherapy. J Ophthalmol. 2017;2017:1917570.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;