Halofantrine-hydrochloride-SKF-102886-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEHalofantrine hydrochlorideCat. No.: HY-A0148ACAS No.: 36167-63-2Synonyms: SKF-102886; WR-171669分式: CHClFNO分量: 536.88作靶点: Parasite作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验

2、DMSO : 30 mg/mL (55.88 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.8626 mL 9.3131 mL 18.6261 mL5 mM 0.3725 mL 1.8626 mL 3.7252 mL10 mM 0.1863 mL 0.9313 mL 1.8626 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体

3、内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 3 mg/mL (5.59 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 Halofantrine hydrochloride (SKF-102886)种通过抑制ERG通道 来延迟整流钾电流的阻滞剂， 种有效的抗疟疾药 1 2。IC50 &

4、 Target Malaria 1.HERG channel 2.REFERENCES1. Krishna S, et al. Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria. Br J Clin Pharmacol. 1993Dec;36(6):585-91.2. Tie, H., et al., Inhibition of HERG potassium channels by the antimalarial agent halofantrine. Br. J. Pharmacol. 130, 1967-1975, (2000)Traebert.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax