GLX351322 - NADPH Oxidase 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGLX351322Cat. No.: HY-100111CAS No.: 835598-94-2分式: CHNOS分量: 431.51作靶点: NADPH Oxidase作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 20 mg/mL (46.35 mM; Need ultrasonic)

2、Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.3174 mL 11.5872 mL 23.1744 mL5 mM 0.4635 mL 2.3174 mL 4.6349 mL10 mM 0.2317 mL 1.1587 mL 2.3174 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂

3、前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.82 mM); Suspended solution; Need ultrasonic2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (4.82 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物

4、活性 GLX351322种 NADPH 氧化酶 4 (Nox4) 抑制剂，在 NOX4 过表达的细胞中，抑制过氧化氢的产，IC50 值为 5 M。IC50 & Target IC50: 5 M (NOX4, cell assay), 40 M (NOX2, cell assay) 1体外研究 GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 M. GLX351322 sho

5、ws weak activity against NOX2 in hPBMC cells(IC50, 40 M).体内研究 GLX351322 (3.8 mg/kg/day, p.o.) ameliorates HFD-induced hyperglycemia in mice 1.REFERENCES1. Anvari E, et al. The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice.Free Radic Res. 2015;49(11):1308-18.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02