药理-药学英语

1、Pharmacology :Neuro- : neuropathy 神经病neuron 神经元neuronal神经细胞neurology神经病学nerve神经neuro-transmitter 神经介质acute 急性 chronic 慢性 subacute 亚急性hemo-和血液有关的hemoglobin 血红蛋白 hemorrhagic 出血的CNS： central nervous systemPNS： peripheral nervous systemdrug development and research药物开发和研究developer展开齐1J-ia :疾病名称ischemia出

2、血状态pneumonia clinical trail临床试验efficacy 疗效 effective. the drugs for the treatment thrombotic 血栓形成的肺炎preclinical 临床前effectiveness 疗效治疗的药物thromb 血栓thrombosis 血栓形成embolic栓塞性的 embolism 栓塞-lysis 溶解：hydrolysis 水解lyse溶解embolus 栓子lympho-淋巴inflame 发炎inflammation 炎症inflammatory response/ reaction炎症反应inflammat

3、ory mediator 炎症介质inter-问 intra-内 intraderinal 皮内reversible 可逆的 irreversible 不可逆的draft label申报材料NDA : new drug application 新药申请erythrocyte 红细胞 leukocytes 白细胞 platelet 血小板infusion 静滴注 venous injection negative control group 阴性对照 treatment group / untreated group blinded assessment 盲法评价静注 bolus injecti

4、on 推注 positive control group 阳性对照未加任何药物的double blind / single blind EAAs excitory amino acids lAAs抑制氨基酸双盲/单盲兴奋氨基酸severe adverse effects 严重不良反应adverse drug reaction (ADR ) 药物不良反应 untoward drug reaction / toxic effectallergic reaction 变态反应过敏反应withdrawal period 停药反应期excitory effect 兴奋效果 inhibitory effe

5、ct抑制效果complication 并发症congestion heart failure CHFchronic heart insufficiency 慢性心功能不全permanent occlusion animals models永久性动物结扎模型transient occlusion animals models暂时性动物结扎模型therapeutic index 治疗指数 Tidose-ranging study 剂量范围确定实验dose-escalation safety trail 剂量递增安全性研究serum 血清 plasma 血浆 whole blood 全血safety

6、 margin 安全界限exposure 暴露量=AUCdiffusion-perfusion magnetic resonance imaging techniques 磁共振扩散灌注影像技术lesion damage injury impairment 损伤facilitated diffusion 易化扩散passive transport 被动转运active transport 主动转运surrogate可替代的surrogate marker 替代标记物tumor marker 月中瘤标记物biomarker 生物标记物oxidase氧化酶sulf-硫ethyl-乙基propyl-

7、丙基ethylene 乙烯methanol 甲醇biological implication生物学作用traumatic brain injury (TBI)创伤性脑损伤decompose ingredient composition component constituent element essence成分cerebral blood flow (CBF)月而血流intracranial pressure (ICP) 颅内压mean blood pressuresystemic blood pressure 全身血压systolic blood pressure (SBP)收缩压dias

8、tolic blood pressure (DBP)舒张压potent diuretic 强效利尿剂free radical scavenger 自 由基清除齐1Jglutamate谷氨酸盐excitotoxic兴奋性毒性thrombus formation血栓形成vascular smooth muscle cell (VSMC)血管平滑肌细胞in vitro cerebral metabolism体外月而细胞代谢nuclear magnetic resonance spectroscopy核磁共振波谱法guinea pig 豚鼠pyruvate丙酮酸盐Krebs cycle三竣酸循环gly

9、colytic糖酵解的lactate乳酸盐alanine丙氨酸mitochondrial proton gradient 线粒体质子梯度be secondary to 继发于 be primary to 原发于parenchyma 脑实质hypometabolism 低代谢penumbral neurons 半暗带神经元secondary damage 继发，性损伤excitatory neurotransmitter兴奋性神经递质neuronal energy crisis 神经元能量代谢异常preventive 预防性secondary damage on penumbral neurou

10、s undergoing cerebral ischemia脑缺血引起的半暗带神经元继发性损伤brain edema 月而水月中cytotoxicity 细胞毒性pathophysiology 病理生理clinical pilot studies临床试验性研究neurological course 神经病变过程administered 给药administering route给药途径cerebral bleeding 月而出血ionotropic receptor channels离子型受体通道oxidative or metabolic stress 氧化或代谢应激hypoperfusio

11、n 血流灌注不足bilateral occlusion 双侧结扎common carotid arteries颈总动脉reoxygenation 复氧electroencephalogram EEP 月而电图Medicinal chemistry ： drug candidate 候选药物 exhibit/ display 显示出 secondary activity 次要活性 motion sickness 晕车病 smoking cessation aid 戒烟药物 angina心绞痛 phosphodiesterase-5 磷酸二酯酶-5 hydrolyze 水解 vasodilator

12、扩血管剂 blood flow血流量 sildenafil citrate 枸檬酸西地那非 given 鉴于drug degradation 药物降解 in vivo 在体 in vitro 体外 sulindac舒林酸 terfenadine 特定 buildup积蓄作用 block the enzyme 抑制酶 metabolite 代谢物 nonsedating antihistamine非镇静抗组胺齐be screened for 被筛选为 second messenger molecular 第二信使分子 enzyme guanylate cyclase 鸟甘酸环化酶 smooth

13、muscle 平滑肌 rational approaches 合理药物设计 trial-and-error反复试验random screening 随机筛选 no intellectualization非智能化sulfa drugs磺胺类药物 when nothing is known about the receptor target未知靶点the National Cancer Institute (NCI)美国国家癌症研究生 a mouse tumor bioassay 小鼠月中瘤生物检测试验 soil samples 土壤样品 streptomycin 链霉素 tetracycline

14、s 四环素 modulation of a specific biological target 特定生物靶点的调控 therapeutic value 治疗价值 biomolecule生物大分子 disease linkage studies 疾病连锁分析 drugable成药性 screening assay药物筛选模型 virtual screen 虚拟筛选法wet screen湿法筛选分析lead discovery先导化合物的发现lead modification 先导化合物的结构优化oral bioavailability口 服生物利用度Lipinskis Rule of Five

15、 Linpinski 的类药 5 原则prototype compound原型化合物computer-aided drug design (CADD )计算机药物辅助设计lead compound 先导化合物structural modification结构优化novel active compounds 新型活性化合物serendipity偶然发现bounded rationality有限合理imbalance 失衡invasion 入侵aberrant cell growth异常细胞生长serotonin 5-羟色胺indomethacin 呷深美辛imatinib 伊马替尼Philade

16、lphia chromosome费城染色体rapidly dividing cells快速分裂的细胞not differentiating between cancer cells and other tissues对癌症细胞和其他正常组织细胞缺乏选择性glycyrrhetinic acid甘草次酸antioxidant activity抗氧化活性in vitro 体外liver microsomes 肝微粒体free radical自由基/游离基hydroxylated 羟基化exhibit 显示了respectively分别是(讲两个东西)-diene 二烯ROS scavenging a

17、ctivity ROS 消除活性reference / positive control阳性对照-keto酮谈基hydroxyl 羟基in view the these results 纵观实验结果pathological 病理atherosclerosis动脉粥样硬化cardiovascular diseases 心血管疾病diabetes糖尿病intervention 干预pharmaceutical agents 药效试齐prophylactic 预防性pharmaceutical research and development药物研发triterpenoid 三菇 licorice

18、甘草 aglycone酉己基 glycyrrhizin 甘草酸 pentacyclic triterpene五环三菇have been shown to 已经显示了 antiulcerative effect 抗溃疡作用 hypolipidemic 降月旨 ammonium salt 钱盐superoxide dismutase (SOD)超氧化歧化酶 malondiadehyde (MDA)丙二醛 cholesterol 胆固醇 triglycerides 甘油三月旨at concentration of 25mg/kg在.的齐1J 量下atherosclerotic 动脉粥样硬化 hypercholesterolemic 高胆固醇 lesion 损伤 carbon tetrachloride 四氯化碳 hepatotoxicity 肝毒性 pseudoaldosteronism 假性醛固酮增多症 cardiovascular active agent 心血管活性药物 proceed a comparative study 进行了 深入的研究 microsomal 微粒体 pharmacophore 药效团 proposed an hypothesis 提出假设 inrefer