Besifovir-LB80331-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBesifovirCat. No.: HY-19447CAS No.: 441785-25-7Synonyms: LB80331分式: CHNOP分量: 299.22作靶点: HBV作通路: Anti-infection储存式: Please store the product under the recommended conditions inthe COA.溶解性数据体外实验 DMSO : 250 mg/mL (835.51 mM; Need u

2、ltrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.3420 mL 16.7101 mL 33.4202 mL5 mM 0.6684 mL 3.3420 mL 6.6840 mL10 mM 0.3342 mL 1.6710 mL 3.3420 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适

3、当保存；以下溶剂前的百分指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.95 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (6.95 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (6.95 mM);

4、Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Besifovir (LB8033)由 LB80380 转化来的种 LB80380 母体药物，进步代谢为其活性形式 LB80317。Besifovir (LB8033)抗型肝炎病毒 (HBV) 的有效抗病毒药物 1 2。REFERENCES1. Jung JA, et al. Pharmacokinetic comparison of the maleate and free base formulations of LB8

5、0380, a novel nucleotide analog, in healthymale volunteers. Int J Clin Pharmacol Ther. 2012 Sep;50(9):657-64.2. Yuen MF, et al. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitisB. Antivir Ther. 2006;11(8):977-83.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-