中医药学循证医学文献阅读课件

1、中医药学循证医学文献阅读Systematic Review系统评价Ginkgo 银杏 记忆医学术语方法之一No Chineseas simple as one word复杂学名记住中文即可GlossaryGinkgo Biloba 5iNkEu 银杏树maidenhair 5meIdEnheE 掌叶铁线蕨intention-to-treat analysis 意向治疗分析neurotransmitter 7njuErEtrAns5mitE 神经递质bias baiEs prejudice 偏见depression di5preFEn sadness 沮丧 抑郁tinnitus ti5naitE

2、s ringing in the ears 耳鸣viscosity vis5kCsiti state of being thick 粘性Ginkgo 5iNkEu意向治疗分析neurotransmitter 7njuErEtrAns5mitE神经递质Sadness 抑郁 Depressiondi5preFEnRinging in the ears耳鸣Tinnitusti5naitEsState of being thick粘性 viscosityvis5kCsiti记忆公共英语单词方法之一No Chineseas simple as one wordPlain English （简朴英语）Gl

3、ossaryrobust rE5bQst strong 精力充沛的substantive 5sQbstEntiv large 大量的cognitive 5kCnitiv get to know 认知的 modification 7mCdifi5keiFEn make change 修正Unconfounded kEn5faundid not confuse 不糊涂的inconsistent7inkEn5sistEnt contradictory 不一致Strong 精力充沛的 RobustrE5bQstContradictory 不一致 inconsistent shape7inkEn5sis

4、tEntGlossaryGinkgo Biloba 白果 (中文即可)Maidenhair 掌叶铁线蕨 (中文即可)Cognitive get to know Substantive large Amendment improveDepression sadness Tinnitus ringing in the ears Viscosity state of being thick医学英语新教程第30章 - p234 阅读16句子Cochrane Library系统综述文摘Learning Objectives of Systematic ReviewTo masterTitleAuthor

5、Structure of SRResult Conclusion To know aboutIntroductionBackgroundObjectiveSearch strategy掌握 标题 (十分简洁)Ginkgo Biloba for cognitive impairment and dementia白果治疗认知损害与痴呆症（Cochrane系统综述）掌握 标题 (十分简洁)Ginkgo Biloba for cognitive impairment and dementia白果治疗认知损害与痴呆症（Cochrane系统综述）掌握标题固定句式:中心词 for 短语 掌握当代(科技)医学

6、英语特点Controlled language（Cochrane 综述文摘）Cochrane ReviewSystematic Review AbstractStructure of Cochrane ReveiwIntroductionBackgroundObjectiveSearch strategySelection criteriaData collection and analysisMain resultsReviews conclusion掌握引言 (修订,截至,被动)A substantive amendment to this systematic review was la

7、st made on 26 August 2002.此系统综述的实质性修改截止2002年8月26日。Background origin 起源 current status 现况 mechanism 机制掌握Background originExtracts of the leaves of the maidenhair tree, Ginkgo biloba, have long been used in China as a traditional medicine for various disorders of health.在中国，从掌叶铁钱蕨白果树叶精华作为传统药物，长期用于治疗各种

8、疾病。 掌握Background status A standardized extract is widely prescribed in Germany and France for the treatment of a range of conditions including memory and concentration problems, confusion, depression, anxiety, dizziness, tinnitus and headache. 掌握背景 现况一种广泛用于德国与法国的标准萃取物可治疗多种疾病，包括记忆与思想集中病症、意识模糊、抑郁、焦虑、头

9、晕、耳鸣与头痛。 掌握Background- mechanismThe mechanisms of action are thought to reflect the action of several components of the extract and include increasing blood supply by dilating blood vessels, reducing blood viscosity, modification of neurotransmitter systems, and reducing the density of oxygen free r

10、adicals. 掌握背景 机制有人认为，若干成分的作用机制是扩张血管、降低血液粘滞度、改善神经递质系统，以及减少氧游离基密度而增加血供 掌握3.Objective - explicit 鲜明 The aim of the review is to assess the efficacy and safety of Ginkgo biloba for the treatment of patients with dementia or cognitive decline.本综述目标是评估白果治疗痴呆症或认知功能减退的有效性与安全性。 掌握Search strategy 3T TimeTypes

11、TermsStrategy Time & Types Trial were identified on 26 June 2002 through a search of the CDCIGsynonym 同义词 & asterisk * The search terms used wereginkgo*,tanakan,EGB-761,EGB761 andEGB 761.所用检索术语为ginkgo*、tanakan、EGB-761、EGB761与“EGB 761”。Selection criteria - phrase+ clauseAll relevant, unconfounded, ra

12、ndomized, double-blind controlled studies, in which extracts of Ginkgo biloba at any strength and over any period were compared with placebo for their effects on people with acquired cognitive impairment, including dementia, of any degree of severity.收录标准收录所有与白果萃取物（任何浓度与任何疗程）治疗获得性认知损害（包括任何类型的痴呆症）相关的

13、正规随机双盲安慰剂对照研究文献。 collection & analysis - metaData for the meta-analyses are based on reported summary statistics for each study.供荟粹分析分析的资料取自每个研究的发表总结性统计。 Main results 先总后分General: 1-4Division (benefit): 5-7 (the same sentence pattern)Summary (adverse): 8-9掌握Main results 先总 概括Overall, there are no si

14、gnificant differences between Ginkgo and placebo in the proportion of participants experiencing adverse events. 在总体上，接受白果与安慰剂受试者的不良反应事件无显著差异。 掌握Main results 先总 - metaThere are benefits (主语) associated with Ginkgo (dose less than 200mg/day) compared with placebo at less than 12 weeks (54/63 showed im

15、provement compared with 20/63, OR 15.32, 95% CI 5.90 to 39.80, P= P 0.01显著意义 0.001极显著意义Main results -先总 - meta与安慰剂对照组相比，至少在12周以内显示白果（剂量200mg/日）相关效益（56/43 比20/63，优势比15.32，95%可信区间5.90至39.80，P=0.0001）。 掌握Main results 3 divisionCognition shows (different data.)Activities show / .Measures of mood show /

16、.Division 后分(疗效)掌握Main results division -metaThere are benefits (主语) associated with Ginkgo (dose less than 200mg/day) compared with placebo at less than 12 weeks (54/63 showed improvement compared with 20/63, OR 15.32, 95% CI 5.90 to 39.80, P=0.0001). 掌握same pattern with different subjects and data

17、Cognition shows benefit for Ginkgo (dose less than 200mg/day) compared with placebo at 12 weeks (SMD -0.57, 95% CI -1.09, -0.05, P=0.03, random effects model). 掌握same pattern with different subjects and dataActivities shows benefit for Ginkgo (dose less than 200mg/day) compared with placebo at 12 we

18、eks (SMD -0.57, 95% CI -1.09, -0.05, P=0.03, random effects model). 掌握same pattern with different subjects and dataMeasures of mood shows benefit for Ginkgo (dose less than 200mg/day) compared with placebo at 12 weeks (SMD -0.57, 95% CI -1.09, -0.05, P=0.03, random effects model). 掌握当代(科技)医学英语特点Cont

19、rolled languageReviewers conclusions Merits Imperfect Prospect掌握Reviewers conclusions 优点Ginkgo biloba appears to be safe in use with no excess side effects compared with placebo.应用白果相对安慰剂无过度副作用，显得(似乎)安全。掌握Reviewers conclusions 说明Many of the early trials used unsatisfactory methods, were small, and w

20、e cannot exclude publication bias.许多早期试验应用效果不满意者多为小型研究,综述者不能排除论文偏倚。掌握Reviewers conclusions -优点Overall there is promising evidence of improvement in cognition and function associated with Ginkgo.总体上讲，白果改善认知与功能依据前景良好。掌握Reviewers conclusions 不足However, the three more modern trials show inconsistent res

21、ults.然而，有个以上当代临床试验的结果不一致。掌握Reviewers conclusions 展望There is need for a large trial using modern methodology and permitting an intention-to-treat analysis to provide robust estimates of the size and mechanism of any treatment effects.尚需应用现代的方法学与“意向治疗分析”大型临床试验，以提供任何治疗效应大小的有力依据与机制。掌握Summary key pointsTitle: 干预 + for + 病症Author : 2, independently Structure of SR: 8 sectionsConclusion: merits; imperfect; prospect掌握结构式文摘与系统综述文摘比较MIA