肿瘤转移英文-课件

1、Cancer metastasisCancer metastasisWhat is metastasis?What is metastasis?Cancer Stem Cells motivate and maintain the growth of cancer cellspotentiality plasticity make them easy to surviveHypothesis of tumor metastasisCancer Stem Cells motivate aThe phases of Cancer metastasisThe mechanism of cancer

2、metastasisMalignant Tumor metastasis pathway Tumor metastasisThe molecules in the metastasis The phases of Cancer metastasiThe phases of Cancer metastasis俞仁涛Invasion(侵犯)Intravasation（内渗）Extravasation（外渗）The phases of Cancer metastasiInvasion1.Stable cell movable cell 2.Protein expression3.Movement m

3、echanismRelative genesInvasion1.Stable cell 肿瘤转移英文-课件Intravasation1.Angiogenesis 2.Immune escape Intravasation1.Angiogenesis ExtravasationThe inverse process of invasionExtravasationThe inverse proceTHE PROCESS OF TUMOR METASTASISTHE PROCESS OF TUMOR METASTASIMalignant Tumor metastasis pathway 恶性肿瘤常

4、见的转移途径Malignant Tumor metastasis patCommon metastasis pathway 1.lymphatic metastasis 淋巴道转移2.hematogenous metastasis 血道转移3. implantation metastasis 种植性转移Common metastasis pathway 1.lProcess ： cancer cell lymph vessel regional lymph node beyond lymph node hematogenous metastasis1. Lymphatic metastasiz

5、eProcess ： cancer cell 2.Hematogenous metastasislungliver2.Hematogenous metastasislunglMetastasis pathway（1） Body vein lung（2） Portal vein liver（3） pulmonary veins Total body （ brain 、 bone 、 kidney 、 adrenal glands ） Metastasis pathway（1） Body vei3.Implantation metastasis ChestCeliacPericardial cav

6、ity3.Implantation metastasis ChesBioremediation 生物治疗Low side effectsWide rangeClear goalBioremediation 生物治疗Low side eMechanism of cell metastasisCell adhesion molecule(CAM)Degradation of extracellular matrixMotility of tumor cellsFormation of vessels Regulation of gene expressionImmunizationMechanis

7、m of cell metastasisCeCell adhesion molecule(CAM)CadherinIntegrinsSelectinIgSFothersCell adhesion molecule(CAM)Cad Degradation of extracellular matrix Degradation of extracellular 丝氨酸蛋白酶类 半胱氨酸蛋白酶类（ Caspase家族）天冬氨酸蛋白酶类 基质金属蛋白酶类（MMPs）Degradation of extracellular matrix Proteoiytic enzymes (蛋白水解酶)溶解ECME

8、CM是肿瘤侵袭和转移的天然屏障丝氨酸蛋白酶类 Degradation of eMotility of tumor cells Motility types: Random movement Directional movement Motility factors:AutoecrineparacrineMotility of tumor cells MotiFormation of vesselsTumor metastasis relys on the forming of vessels.Formation of vesselsTumor metBrief Introduction to

9、Molecules in Cancer Metastasis肿瘤转移英文-课件Three SectionsTumour angiogenesis DisaggregationIntravasationThree SectionsTumour angiogeneTumour angiogenesis Tumour angiogenesis has laid the foundation for tumour survival and tumour metastasis .Tumour angiogenesis Tumour angTumour angiogenesis Tumour angiogenes