磷酸化活化转录因子1抗体供应

1、磷酸化活化转录因子1抗体供应别名ATF1(phosphoS63);p-ATF1(phosphoS63);ActivatingTranscriptionFactor1;TREB36protein;ATF1;ATF1EWSfusiongeneATF1FUSfusiongene;cAMPdependenttranscriptionfactor1;CyclicAMPdependenttranscriptionfactorATF1;CyclicAMPdependenttranscriptionfactorATF1;EWSAFT1;FUSATF1;RNAbindingproteinactivatingtr

2、anscriptionfactor1fusionprotein;TREB36;TREB36.浓度1mg/1ml规格0.1ml/100g抗体来源Rabbit克隆类型polyclonal交叉反应Human,Mouse产品类型一抗磷酸化抗体研究领域转录调节因子表观遗传学蛋白分子量predictedmolecularweight:29kDa性状LyophilizedorLiquid免疫原KLHconjugatedsynthesisedphosphopeptidederivedfromhumanATF1aroundthephosphorylationsiteofSer63亚型IgG纯化方法affinit

3、ypurifiedbyProteinA储存液Preservative:15mMSodiumAzide,Constituents:1%BSA,0.01MPBS,pH7.4产品应用WB=1:100-500ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（石蜡切片需做抗原修复）notyettestedinotherapplications.optimaldilutions/concentrationsshouldbedeterminedbytheenduser.保存条件Storeat-20Cforoneye

4、ar.Avoidrepeatedfreeze/thawcycles.Thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20C.WhenreconstitutedinsterilepH7.40.01MPBSordiluentofantibodytheantibodyisstableforatleasttwoweeksat2-4C.ImportantNoteThisproductassuppliedisintendedforresearchuseonly

5、,notforuseinhuman,therapeuticordiagnosticapplications.产品介绍ATF1(ActivatingTranscriptionFactor1,TREB-36)isamemberoftheATF/CREBfamilyofbasicregionleucine-zipper(bZip)DNA-bindingproteinsthatregulatestranscriptionbybindingtoaconsensuscAMPresponseelement(CRE)inthepromoter磷酸化活化转录因子1抗体供应ofvariousviralandcel

6、lulargenes.Manyofthesegenesareimportantincellgrowthanddifferentiation,andinstressandimmuneresponses.TheactivationfunctionofCRE-bindingproteinsmaybemodulatedbyphosphorylationofseveralkinasesandismediatedbycoactivatorssuchasCREB-bindingprotein(CBP)andp300.ATF1isanuclearproteinthatbindsDNAasahomodimero

7、rasheterodimerswiththeinducibletranscriptionfactorsCREB1orCREM.Heterodimersappeartobestrongertranscriptionalactivatorsthanthehomodimers.TissueexpressionofATF1mRNAiswidespread.SeveralisoformsofATF1arisebydifferentialsplicing.ATF1mediatesbothCa2+andcAMPresponsesatseverallevels.ItbindstotheTax-responsi

8、veelement(TRE1)ofthehumanT-celllymphotropicvirustype-I(HTLV1).ATF1isdetectableinmetastaticmelanomacellsandseemstocontributetotheirsurvival.AchimericproteincomposedoftheN-terminaldomainofEWS(Ewingsarcomaoncogene)linkedtothebZipdomainofATF1isimplicatedintheraremalignantclearcellsarcomaoftendonsheathan

9、daponeuroses(malignantmelanomaofsoftparts).Function:ThisproteinbindsthecAMPresponseelement(CRE)(consensus:5-GTGACGTACAG-3),asequencepresentinmanyviralandcellularpromoters.BindstotheTax-responsiveelement(TRE)ofHTLV-I.MediatesPKA-inducedstimulationofCRE-reportergenes.SubcellularLocation:Nucleus.DISEAS

10、E:DefectsinATF1maybeacauseofangiomatoidfibroushistiocytoma(AFH)MIM:612160.Adistinctvariantofmalignantfibroushistiocytomathattypicallyoccursinchildrenandadolescentsandismanifestbynodularsubcutaneousgrowth.Characteristicmicroscopicfeaturesincludelobulatedsheetsofhistiocyte-likecellsintimatelyassociate

11、dwithareasofhemorrhageandcysticpseudovascularspaces,aswellasastrikingcuffingofinflammatorycells,mimickingalymphnodemetastasis.Note=ChromosomalaberrationsinvolvingATF1arefoundinpatientswithangiomatoidfibroushistiocytoma.Translocationt(12;16)(q13;p11.2)withFUSgeneratesachimericATF1/FUSprotein.Transloc

12、ationt(12;22)(q13;q12)withEWSR1generatesachimericATF1/EWSR1protein.Similarity:BelongstothebZIPfamily.ATFsubfamily.Contains1bZIPdomain.Contains1KID(kinase-inducible)domain.E-(Hu)（03）-01041 人周期素依赖性激酶1(CDK-1)elisa试剂盒 ，英文名： Cyclin-dependentkinase1,CDK-1ELISAKit ，规格： 96T/48TE-(Hu)（03）-01042 人磷酸化腺苷酸活化蛋白激酶

13、(AMPK)elisa试剂盒 ，英文名： Phosphorylatedadenosinemonophosphateactivatedproteinkinase,AMPKELISAKit ，规格： 96T/48TE-(Hu)（03）-01043 人解整合素样金属蛋白酶9(ADAM9)elisa试剂盒 ，英文名： ADisintegrinAndMetalloprotease9,ADAM9ELISAKit ，规格： 96T/48TE-(Hu)（03）-01044 人位淀粉样前体蛋白裂解酶2(BACE2)elisa试剂盒 ，英文名： beta-siteAPP-cleavingenzyme2,BACE2

14、ELISAKit ，规格： 96T/48TE-(Hu)（03）-01045 人尿嘧啶核苷磷酸化酶1(UPP1)elisa试剂盒 ，英文名： uridinephosphorylase1,UPP1ELISAKit ，规格： 96T/48TE-(Hu)（03）-01046 人乙醇脱氢酶(ADH)elisa试剂盒 ，英文名： alcoholdehydrogenase,ADHELISAKit ，规格： 96T/48TE-(Hu)（03）-01047 人乙醛脱氢酶(ALDH)elisa试剂盒 ，英文名： aldehydedehydrogenase,ALDHELISAKit ，规格： 96T/48TE-(H

15、u)（03）-01048 人Rho家族GTP酶1(RND1)elisa试剂盒 ，英文名： RhofamilyGTPase1,RND1ELISAKit ，规格： 96T/48TE-(Hu)（03）-01049 人受体TNFRSF结合丝氨酸苏氨酸激酶2(RIPK2)elisa试剂盒 ，英文名： receptorTNFRSF-interactingserine-threoninekinase2,RIPK2ELISAKit ，规格： 96T/48TE-(Hu)（03）-01050 人磷脂爬行酶1(PLSCR1)elisa试剂盒 ，英文名： phospholipidscramblase1,PLSCR1E

16、LISAKit ，规格： 96T/48TE-(Hu)（03）-01051 人3-羟基-3-甲基戊二酰辅酶A合酶1(HMGCS1)elisa试剂盒 ，英文名： 3-hydroxy-3-methylglutaryl-CoenzymeAsynthase1,HMGCS1ELISAKit ，规格： 96T/48TE-(Hu)（03）-01052 人嗜酸性白血球相关之RNA水解酵素家族成员12(EAR12)elisa试剂盒 ，英文名： eosinophil-associatedribonucleaseAfamilymember12,EAR12ELISAKit ，规格： 96T/48TE-(Hu)（03）-01053 人嗜酸性白血球相关之RNA水解酵素家族成员3(EAR3)elisa试剂盒 ，英文名： eosinophil-associatedribonucleaseAfamilymember3,EAR3ELISAK